Document Detail

Accelerated utilization of lactate under the effect of hypoxen after intensive exercise.
MedLine Citation:
PMID:  19023968     Owner:  NLM     Status:  MEDLINE    
Administration of substrates of energy metabolism in combination with hypoxen (sulfur-containing oligoquinone) promoted the increase in blood lactate concentration during maximum exercise, accelerated lactate utilization, and reduced the lactate/pyruvate ratio during recovery. The in vivo effects are in line with hypoxen capacity to accelerate in vitro oxidation of exogenous NADH in mitochondria by the non-rotenone-dependent pathway realized with participation of cytochrome C.
E V Grishina; Ya V Khaustova; V G Pogorelova; A G Pogorelov; M K Kuz'mich; E I Maevskii
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bulletin of experimental biology and medicine     Volume:  145     ISSN:  0007-4888     ISO Abbreviation:  Bull. Exp. Biol. Med.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2008-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372557     Medline TA:  Bull Exp Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  198-201     Citation Subset:  IM    
Laboratory of Biosystems Thermodynamics and Energy, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino.
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MeSH Terms
Energy Metabolism
Lactates / metabolism*
Mitochondria, Liver / metabolism
NAD / metabolism
Oxygen Consumption
Phenyl Ethers / metabolism*
Physical Conditioning, Animal*
Pyruvic Acid / metabolism
Rats, Wistar
Reg. No./Substance:
0/Lactates; 0/Phenyl Ethers; 127-17-3/Pyruvic Acid; 148465-31-0/olifen; 53-84-9/NAD

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