| Accelerated total dose infusion of low molecular weight iron dextran is safe and efficacious in chronic kidney disease patients. | |
| | |
MedLine Citation:
|
PMID: 20956457 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: Low molecular weight iron dextran (LMWID) is licensed for use as a total dose infusion (TDI) over 4-6 h. In order to improve patient convenience and cost-effectiveness of therapy, we investigated the safety and efficacy of adopting accelerated dosing regimens and compared this with a standard rate LMWID infusion. METHODS: A retrospective study of patients undergoing accelerated and standard rate TDI of LMWID was conducted across three centres. A total of 1904 doses of LMWID were administered at an accelerated rate of 1 g over 1 h 40 min. This was compared with 395 patients who had standard rate infusion of 1 g LMWID over 3-4 h. RESULTS: There were eight minor adverse events in patients receiving accelerated dose LMWID (8/1904, 0.42%) in comparison to one adverse event in patients receiving a standard regimen (1/395, 0.25%). No serious adverse events occurred. Serum haemoglobin and ferritin significantly improved in both groups. CONCLUSION: TDI LMWID is a safe and efficacious method of iron replacement. Accelerated infusion regimen is safe and compares well with standard rate infusion regimen. Furthermore, accelerated TDI of LMWID enables greater numbers of patients to be treated and consequently there appear to be advantages for both patient and health resources. |
| | |
Authors:
|
S Sinha; D Chiu; G Peebles; P Swoboda; S Kolakkat; E Lamerton; S Fenwick; S Bhandari; P A Kalra |
Related Documents
:
|
6181507 - 5-azacytidine stimulates fetal hemoglobin synthesis in anemic baboons. 6616457 - Effect of methotrexate with 5-methyltetrahydrofolate rescue and dietary homocystine on ... 406997 - Dose-dependent metabolism of methotrexate in man and rhesus monkeys. 6200387 - Trophoblastic cell sensitivity to 8-day chemotherapy in nonmetastatic gestational troph... 2124087 - Pharmacokinetics of the contraceptive steroids levonorgestrel and gestodene after singl... 21963057 - Diagnostic performance of high-definition coronary computed tomography angiography perf... |
Publication Detail:
|
Type: Journal Article Date: 2010-10-18 |
Journal Detail:
|
Title: QJM : monthly journal of the Association of Physicians Volume: 104 ISSN: 1460-2393 ISO Abbreviation: QJM Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-02-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9438285 Medline TA: QJM Country: England |
Other Details:
|
Languages: eng Pagination: 221-30 Citation Subset: IM |
Affiliation:
|
Department of Renal Medicine, Hope Hospital, Stott Lane, Salford, M6 8HD, UK. philip.kalra@srft.nhs.uk. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ethnic differences in common carotid intima-media thickness, and the relationship to cardiovascular ...
Next Document: No evidence of RET germline mutations in familial pituitary adenoma.