| Accelerated subclinical coronary atherosclerosis in patients with familial hypercholesterolemia. | |
| | |
MedLine Citation:
|
PMID: 22018443 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: We determined the extent, severity, distribution and type of coronary plaques in cardiac asymptomatic patients with familial hypercholesterolemia (FH) using computed tomography (CT). BACKGROUND: FH patients have accelerated progression of coronary artery disease (CAD) with earlier major adverse cardiac events. Non-invasive CT coronary angiography (CTCA) allows assessing the coronary plaque burden in asymptomatic patients with FH. MATERIALS AND METHODS: A total of 140 asymptomatic statin treated FH patients (90 men; mean age 52±8 years) underwent CT calcium scoring (Agatston) and CTCA using a Dual Source CT scanner with a clinical follow-up of 29±8 months. The extent, severity (obstructive or non-obstructive plaque based on >50% or <50% lumen diameter reduction), distribution and type (calcified, non-calcified, or mixed) of coronary plaque were evaluated. RESULTS: The calcium score was 0 in 28 (21%) of the patients. In 16% of the patients there was no CT-evidence of any CAD while 24% had obstructive disease. In total 775 plaques were detected with CT coronary angiography, of which 11% were obstructive. Fifty four percent of all plaques were calcified, 25% non-calcified and 21% mixed. The CAD extent was related to gender, treated HDL-cholesterol and treated LDL-cholesterol levels. There was a low incidence of cardiac events and no cardiac death occurred during follow-up. CONCLUSION: Development of CAD is accelerated in intensively treated male and female FH patients. The extent of CAD is related to gender and cholesterol levels and ranges from absence of plaque in one out of 6 patients to extensive CAD with plaque causing >50% lumen obstruction in almost a quarter of patients with FH. |
| | |
Authors:
|
Lisan A Neefjes; Gert-Jan R Ten Kate; Rossi Alexia; Koen Nieman; Annette J Galema-Boers; Janneke G Langendonk; Annick C Weustink; Nico R Mollet; Eric J Sijbrands; Gabriel P Krestin; Pim J de Feyter |
Related Documents
:
|
21323683 - Molecular biology-based assessment of vitamin e-coated dialyzer effects on oxidative st... 21700833 - Serum bilirubin levels in familial hypercholesterolemia: a new risk marker for cardiova... 6228953 - Percutaneous transluminal angioplasty of the iliac arteries: intravenous digital subtra... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-8 |
Journal Detail:
|
Title: Atherosclerosis Volume: - ISSN: 1879-1484 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
|
Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands; Interuniversitair Cardiologisch Instituut Nederland, Utrecht, The Netherlands; Department of Cardiology, Thorax Center, Rotterdam, The Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: From the impact of french guidelines to reduce episiotomy's rate.
Next Document: Density of dental practitioners and access to dental care for the elderly: A multilevel analysis wit...