| Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide. | |
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MedLine Citation:
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PMID: 20375903 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To explore whether the accelerated senescence of endothelial progenitor cells (EPCs) is related to the reduction of calcitonin gene-related peptide (CGRP) in hypertension. METHODS AND RESULTS: In-vivo studies, plasma levels of CGRP and the number of senescent EPCs were measured in hypertensive humans and animals, from which the EPCs were isolated to examine the production of CGRP. Moreover, rutaecarpine, as an agent or tool to stimulate CGRP production, was used in hypertensive animals. The effects of rutaecarpine on angiotensin II-induced EPCs senescence were evaluated in vitro. The results showed that the number of circulating senescent EPCs was significantly increased in hypertension concomitantly with the decreased plasma level of CGRP and the decreased CGRP mRNA expression in EPCs. Administration of rutaecarpine reversed EPC senescence along with an elevation in CGRP production in spontaneously hypertensive rats. In the angiotensin II-induced EPCs senescence, the CGRP mRNA expression was reduced, which was reversed by rutaecarpine. The effect of rutaecarpine on EPCs was canceled in the presence of capsazepine, a selective antagonist of transient receptor potential vanilloid 1. CONCLUSION: The results suggest that CGRP may work as an endogenous protective substance to counteract EPCs senescence in hypertension and the accelerated EPCs senescence in hypertension was related to the reduction of CGRP. |
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Authors:
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Zhi Zhou; Jun Peng; Chen-Jing Wang; Dai Li; Ting-Ting Li; Chang-Ping Hu; Xiao-Ping Chen; Yuan-Jian Li |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 28 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-16 Completed Date: 2010-07-29 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 931-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Adult Stem Cells / drug effects, metabolism, pathology* Angiotensin II / pharmacology Animals Base Sequence Calcitonin Gene-Related Peptide / biosynthesis, blood*, genetics Capsaicin / analogs & derivatives, pharmacology Cell Aging* / drug effects DNA Primers / genetics Endothelial Cells / drug effects, metabolism, pathology* Female Humans Hypertension / blood*, genetics, pathology* Indole Alkaloids / pharmacology Male Middle Aged Quinazolines / pharmacology RNA, Messenger / genetics, metabolism Rats Rats, Inbred SHR Rats, Inbred WKY TRPV Cation Channels / genetics |
| Chemical | |
Reg. No./Substance:
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0/DNA Primers; 0/Indole Alkaloids; 0/Quinazolines; 0/RNA, Messenger; 0/TRPV Cation Channels; 0/TRPV1 protein, human; 0/capsazepine; 11128-99-7/Angiotensin II; 404-86-4/Capsaicin; 83652-28-2/Calcitonin Gene-Related Peptide; 84-26-4/rutecarpine |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2010 May;28(5):887-8
[PMID:
20395748
]
J Hypertens. 2010 Oct;28(10):2169-70; author reply 2171 [PMID: 20844372 ] J Hypertens. 2010 Oct;28(10):2170-1; author reply 2171 [PMID: 20844373 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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