| Accelerated response to reinoculation in experimental allergic encephalomyelitis: clinical study. | |
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MedLine Citation:
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PMID: 1804798 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An attack of experimental allergic encephalomyelitis is generally thought to confer resistance to a second attack. Nevertheless, some authors have produced second attacks, sometimes with an anamnestic shortening of the incubation period. In addition, second attacks of experimental allergic encephalomyelitis with accelerated onsets following reinoculation were found in every experiment when histopathologic rather than clinical criteria were employed. In the present work, we found that clinical signs with accelerated onset were also found in each experiment provided that the first attack was produced with the aid of Freund's complete adjuvant and provided that the reinoculation stimulus was the highly potent combination of rat spinal cord and carbonyl iron. Whatever the potency of the reinoculation, and regardless of the occurrence of an accelerated onset, the eventual outcome was a decreased severity and mortality of the second attack of experimental allergic encephalomyelitis. The new data demonstrate that accelerated onset is not necessarily an indication of increased severity. |
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Authors:
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S Levine; A Saltzman |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International archives of allergy and applied immunology Volume: 96 ISSN: 0020-5915 ISO Abbreviation: Int. Arch. Allergy Appl. Immunol. Publication Date: 1991 |
Date Detail:
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Created Date: 1992-05-01 Completed Date: 1992-05-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404561 Medline TA: Int Arch Allergy Appl Immunol Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 259-62 Citation Subset: IM |
Affiliation:
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Pathology Department, New York Medical College, Valhalla. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic Animals Autoantigens / administration & dosage, immunology Encephalomyelitis, Autoimmune, Experimental / immunology* Female Immunologic Memory Nerve Tissue Proteins / administration & dosage, immunology Rats Rats, Inbred Lew Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Autoantigens; 0/Nerve Tissue Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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