Document Detail

Accelerated response to reinoculation in experimental allergic encephalomyelitis: clinical study.
MedLine Citation:
PMID:  1804798     Owner:  NLM     Status:  MEDLINE    
An attack of experimental allergic encephalomyelitis is generally thought to confer resistance to a second attack. Nevertheless, some authors have produced second attacks, sometimes with an anamnestic shortening of the incubation period. In addition, second attacks of experimental allergic encephalomyelitis with accelerated onsets following reinoculation were found in every experiment when histopathologic rather than clinical criteria were employed. In the present work, we found that clinical signs with accelerated onset were also found in each experiment provided that the first attack was produced with the aid of Freund's complete adjuvant and provided that the reinoculation stimulus was the highly potent combination of rat spinal cord and carbonyl iron. Whatever the potency of the reinoculation, and regardless of the occurrence of an accelerated onset, the eventual outcome was a decreased severity and mortality of the second attack of experimental allergic encephalomyelitis. The new data demonstrate that accelerated onset is not necessarily an indication of increased severity.
S Levine; A Saltzman
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International archives of allergy and applied immunology     Volume:  96     ISSN:  0020-5915     ISO Abbreviation:  Int. Arch. Allergy Appl. Immunol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-05-01     Completed Date:  1992-05-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404561     Medline TA:  Int Arch Allergy Appl Immunol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  259-62     Citation Subset:  IM    
Pathology Department, New York Medical College, Valhalla.
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MeSH Terms
Adjuvants, Immunologic
Autoantigens / administration & dosage,  immunology
Encephalomyelitis, Autoimmune, Experimental / immunology*
Immunologic Memory
Nerve Tissue Proteins / administration & dosage,  immunology
Rats, Inbred Lew
Time Factors
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Autoantigens; 0/Nerve Tissue Proteins

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