Document Detail

Accelerated rejection of allografted rat liver perfused with anti-ICAM-1 monoclonal antibody.
MedLine Citation:
PMID:  1362713     Owner:  NLM     Status:  MEDLINE    
Infusion of mouse anti-rat ICAM-1 into the portal vein of ACI rat liver graft before transplantation resulted in accelerated rejection by LEW recipients (2.9 +/- 2.5 days), when compared to the ACI liver grafts perfused with either Lactate-Ringer's solution (9.8 +/- 1.3) or anti-human ICAM-1 mAb (9.8 +/- 3.1). Histologic features of anti-rat ICAM-1 perfused grafts were spotty ischemic necrosis, whereas those of control grafts were marked cellular infiltration. These combined survival and histologic data suggest that the accelerated rejection may be mediated by vascular deterioration.
T Omura; H Ishikura; Y Nakajima; C Takahashi; J Kimura; J Uchino; T Yoshiki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunobiology     Volume:  186     ISSN:  0171-2985     ISO Abbreviation:  Immunobiology     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-03-03     Completed Date:  1993-03-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  241-5     Citation Subset:  IM    
Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan.
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MeSH Terms
Antibodies, Monoclonal / immunology*
Cell Adhesion Molecules / immunology*
Graft Rejection / chemically induced*,  etiology*,  pathology
Graft Survival / drug effects
Intercellular Adhesion Molecule-1
Liver Transplantation / immunology*
Rats, Inbred ACI
Transplantation, Homologous
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Cell Adhesion Molecules; 126547-89-5/Intercellular Adhesion Molecule-1

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