Document Detail

Accelerated partial breast irradiation using the MammoSite device: early technical experience and short-term clinical follow-up.
MedLine Citation:
PMID:  17058738     Owner:  NLM     Status:  MEDLINE    
The MammoSite brachytherapy system is a novel form of intracavitary accelerated partial breast irradiation (APBI) that allows treatment over a 5- to 7-day course after breast conserving surgery (BCS). Fifty-one patients with invasive breast carcinoma underwent BCS and APBI using the MammoSite device, with 30 (59%) patients having drain placement in the lumpectomy cavity. Main outcome measures included time to initiating APBI, cosmesis using the Harvard Scale, and local and distant tumor recurrence with short-term follow-up. Five (9.8%) devices were explanted because of unfavorable final pathological findings or infection. Mean time to the start of APBI in patients without drain placement was 7.2 days (range, 5-12 days) compared with 5.1 days (range, 3-8 days) in patients with drains (P = 0.003). Cosmetic results were excellent in 25 (54.3%) patients, good in 19 (41.3%) patients, and fair in 2 (4.4%) patients. With a mean follow-up of 16 months (range, 6-38 months), no ipsilateral breast recurrences developed in any of the 51 patients. Thirteen patients had at least a 2-year follow-up. Two patients developed brain metastases and died at 19 and 23 months, respectively. The favorable short-term outcomes support further studies comparing APBI with standard whole-breast irradiation in patients undergoing BCS.
Peter I Tsai; Marianne Ryan; Kelly Meek; Monica C Ryoo; Michael Tome; Jan Takasugi; Philip Haigh; L Andrew Difronzo
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American surgeon     Volume:  72     ISSN:  0003-1348     ISO Abbreviation:  Am Surg     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2006-11-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370522     Medline TA:  Am Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  929-34     Citation Subset:  IM    
Department of Surgery, Kaiser Permanente Los Angeles Medical Center, California, USA.
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MeSH Terms
Aged, 80 and over
Brachytherapy / adverse effects,  instrumentation*,  methods
Brain Neoplasms / secondary
Breast / radiation effects*
Breast Neoplasms / radiotherapy*,  surgery
Carcinoma, Ductal, Breast / radiotherapy,  secondary,  surgery
Cause of Death
Follow-Up Studies
Mastectomy, Segmental
Middle Aged
Neoplasm Recurrence, Local / pathology
Skin / radiation effects
Time Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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