Document Detail

Accelerated maturation of fetal ductus arteriosus by maternally administered vitamin A in rats.
MedLine Citation:
PMID:  9585009     Owner:  NLM     Status:  MEDLINE    
Maturation of fetal ductus arteriosus is associated with increased constriction in response to maternally administered indomethacin. Recently retinoic acid has been shown to be important in development of the fetal ductus arteriosus. To determine whether retinoid might be of value in the treatment of patent ductus arteriosus in premature infants, we studied the response of fetal ductus arteriosus to indomethacin with and without pretreatment with vitamin A (1 mg (3000 IU)/kg, intramuscular injection) in near-term and preterm rats. Maturation of the ductus arteriosus was studied by measuring the inner diameters of the ductus arteriosus (D) and main pulmonary artery (P) to get D/P ratio 4 h after orogastric administration of 1 mg/kg indomethacin. D/P was 1.0 in the fetus before administration of indomethacin. In near-term fetuses on the 21st d without vitamin A, D/P decreased to 0.54 with indomethacin, whereas it decreased to 0.27 (p < 0.05) in those with pretreatment with vitamin A on the 19th and 20th d. In preterm fetuses on the 20th d without pretreatment with vitamin A, D/P decreased to 0.82 with indomethacin, whereas it decreased to 0.66 (p < 0.05) in those with pretreatment with vitamin A on the 19th d. It is concluded that maternally administered vitamin A accelerates maturation of the ductus arteriosus in fetal rats.
K Momma; M Toyono; S Miyagawa-Tomita
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric research     Volume:  43     ISSN:  0031-3998     ISO Abbreviation:  Pediatr. Res.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-06-16     Completed Date:  1998-06-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0100714     Medline TA:  Pediatr Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  629-32     Citation Subset:  IM    
Department of Pediatric Cardiology, The Heart Institute of Japan, Tokyo Women's Medical College.
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MeSH Terms
Analysis of Variance
Ductus Arteriosus / drug effects,  embryology*
Embryonic and Fetal Development
Gestational Age
Indomethacin / pharmacology
Rats, Wistar
Tretinoin / pharmacology*
Vasoconstriction / drug effects
Vasodilation / drug effects
Vitamin A / analogs & derivatives*,  pharmacology
Reg. No./Substance:
11103-57-4/Vitamin A; 302-79-4/Tretinoin; 53-86-1/Indomethacin; 79-81-2/retinol palmitate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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