| Accelerated malignant conversion of human HBL-100 cells by the v-Ki-ras oncogene. | |
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MedLine Citation:
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PMID: 2836229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The human epithelial HBL-100 cell line harbors SV40 genetic information and has an unlimited growth potential. Despite displaying properties characteristic of transformation since its early in vitro passages, it is capable of producing progressively growing tumors in nude mice only after long-term culture. This is a reproducible phenomenon and apparently not the consequence of a selection of preexisting malignant cells. Superinfection of early passage nontumorigenic HBL-100 cells with Kirsten murine sarcoma virus, which contains a Ki-ras oncogene having undergone multiple activating events, induces morphologic alterations and rapidly converts the cells to neoplastic cells, further supporting the hypothesis of multistep carcinogenesis. The HBL-100 cell line might be useful in defining the oncogenes representative of different families, which are able to complement SV40 in this system. |
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Authors:
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C Saint-Ruf; P Nardeux; S Estrade; D Brouty-Boye; C Lavialle; J S Rhim; R Cassingena |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental cell research Volume: 176 ISSN: 0014-4827 ISO Abbreviation: Exp. Cell Res. Publication Date: 1988 May |
Date Detail:
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Created Date: 1988-07-06 Completed Date: 1988-07-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0373226 Medline TA: Exp Cell Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 60-7 Citation Subset: IM |
Affiliation:
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ER 278, Institut de Recherches Scientifiques sur le Cancer, Villejuif, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Line Cell Transformation, Neoplastic* / pathology Genes, ras* Humans Karyotyping Oncogene Proteins, Viral / metabolism* Simian virus 40 |
| Chemical | |
Reg. No./Substance:
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0/Oncogene Proteins, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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