Document Detail

Accelerated induction of bladder cancer in patched heterozygous mutant mice.
MedLine Citation:
PMID:  15026327     Owner:  NLM     Status:  MEDLINE    
The PATCHED (PTC) gene is recognized as a tumor suppressor in basal cell carcinoma. Mapping of a minimal region of deletion at 9q22.3 and observation of a decreased PTC expression in superficial papillary bladder tumors led us to hypothesize that it could also be involved in this cancer. To further investigate this hypothesis, we submitted Ptc(+/-) heterozygous mutant mice and their wild-type littermates to chemical carcinogenesis by adding N-butyl-N-(4-hydroxybutyl) nitrosamine to their drinking water. Preneoplastic and neoplastic changes were observed significantly earlier in the Ptc(+/-) than in the wild-type mice. Our data support the hypothesis of Ptc acting as a tumor suppressor gene in bladder cancer.
Sahar Hamed; Hélène LaRue; Hélène Hovington; Johanne Girard; Lucie Jeannotte; Eva Latulippe; Yves Fradet
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  64     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-03-17     Completed Date:  2004-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1938-42     Citation Subset:  IM    
Laval University Cancer Research Centre, Centre Hospitalier Universitaire de Québec-L'Hôtel-Dieu de Québec, 11 Côte du Palais, Québec City, Québec G1R 2J6, Canada.
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MeSH Terms
Butylhydroxybutylnitrosamine / toxicity
Carcinoma, Transitional Cell / chemically induced,  genetics
Cell Division
Gene Deletion
In Situ Nick-End Labeling
Intracellular Signaling Peptides and Proteins
Membrane Proteins / genetics*
Mice, Inbred C57BL
Neoplasm Invasiveness / genetics,  pathology
Receptors, Cell Surface
Urinary Bladder / physiology
Urinary Bladder Neoplasms / chemically induced,  genetics*
Reg. No./Substance:
0/Carcinogens; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Receptors, Cell Surface; 0/patched receptors; 3817-11-6/Butylhydroxybutylnitrosamine

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