Document Detail


Accelerated growth and improved nutritional status after recombinant human growth hormone (rhGH) therapy in uremic children.
MedLine Citation:
PMID:  10914434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of recombinant human growth hormone (Norditropin, Novonordisk) was studied in 6 children (4 boys and 2 girls) on maintenance hemodialysis, age 13.8 (range 11-17) years. The recombinant human growth hormone (rhGH) was given in a dose of 4 IU/m2/day s.c. Height velocity was followed 6 months before therapy (washout period) and 6 and 12 months later. Growth was estimated by use of Holtain stadiometer in the same conditions and by the same investigator. Nutritional status was assessed by anthropometric measurements including triceps skinfold thickness (TST), midarm muscle circumference (MAMC), and lean body mass (LBM), as well as serum albumin concentration. The mean height velocity increased from 1.67 +/- 0.98, before therapy to 3.33 +/- 1.25 and 6.70 +/- 0.9 cm 6 and 12 months after therapy, respectively (p < 0.001). Body weight also increased during the treatment period from 29.45 +/- 5.24 to 30.96 +/- 6.4 and 31.68 +/- 6.42 kg (p < 0.02) and so did body surface area from 1.01 +/- 0.12 to 1.07 +/- 0.13 and 1.15 +/- 0.1 m2 (p < 0.001). LBM increased from 26.8 +/- 5.4 to 29.85 +/- 6.42 and 31.1 +/- 7.01 kg 6 and 12 months after therapy (p < 0.001). There was a decrease in TST from 7.35 +/- 1.8 to 6.8 +/- 2.18 and 6.8 +/- 2.4 mm (p < 0.3, NS), and an increase in MAMC from 15.15 +/- 2.42 to 16.1 +/- 2.4 and 17.63 +/- 2.6 cm 6 and 12 months after therapy (p < 0.001). Serum albumin concentration increased from 33.5 +/- 1.22 to 36.0 +/- 2.4 and 38.66 +/- 1.03 g/L (p < 0.001). Nutrition parameters confirmed the beneficial effect of rhGH therapy. The authors recommend rhGH therapy in uremic children with growth retardation as well as in any case of malnutrition in these patients.
Authors:
N Ivanovski; Z Antova; K Cakalaroski; M Polenaković
Related Documents :
19264574 - Efficacy of the long-acting repeatable formulation of the somatostatin analogue octreot...
11080404 - Laparoscopic adrenalectomy by the anterior transperitoneal approach: results of 108 ope...
17180554 - Posterior retroperitoneoscopic adrenalectomy: a comparison between the initial experien...
3580774 - Tetracycline sclerotherapy for hydroceles and epididymal cysts.
23964994 - Variability of skin autofluorescence measurement over 6 and 12 weeks and the influence ...
21876824 - Predictors of developing significant mitral regurgitation following percutaneous mitral...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta medica Croatica : c̆asopis Hravatske akademije medicinskih znanosti     Volume:  54     ISSN:  1330-0164     ISO Abbreviation:  Acta Med Croatica     Publication Date:  2000  
Date Detail:
Created Date:  2000-08-24     Completed Date:  2000-08-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9208249     Medline TA:  Acta Med Croatica     Country:  CROATIA    
Other Details:
Languages:  eng     Pagination:  7-10     Citation Subset:  IM    
Affiliation:
Department of Nephrology, University Clinical Centre, Skopje, Republic of Macedonia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Body Constitution
Child
Female
Growth / drug effects*
Growth Disorders / drug therapy*,  etiology
Human Growth Hormone / therapeutic use*
Humans
Male
Nutritional Status*
Recombinant Proteins / therapeutic use
Serum Albumin / analysis
Skinfold Thickness
Uremia / complications*
Weight Gain
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 0/Serum Albumin; 12629-01-5/Human Growth Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Unique cellular features in a testicular plasmacytoma.
Next Document:  Transcranial Doppler sonography in patients with Meniére's disease.