| Accelerated design of bioconversion processes using automated microscale processing techniques. | |
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MedLine Citation:
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PMID: 12480348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Microscale processing techniques are rapidly emerging as a means to increase the speed of bioprocess design and reduce material requirements. Automation of these techniques can reduce labour intensity and enable a wider range of process variables to be examined. This article examines recent research on various individual microscale unit operations including microbial fermentation, bioconversion and product recovery techniques. It also explores the potential of automated whole process sequences operated in microwell formats. The power of the whole process approach is illustrated by reference to a particular bioconversion, namely the Baeyer-Villiger oxidation of bicyclo[3.2.0]hept-2-en-6-one for the production of optically pure lactones. |
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Authors:
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Gary J Lye; Parviz Ayazi-Shamlou; Frank Baganz; Paul A Dalby; John M Woodley |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Trends in biotechnology Volume: 21 ISSN: 0167-7799 ISO Abbreviation: Trends Biotechnol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-13 Completed Date: 2003-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8310903 Medline TA: Trends Biotechnol Country: England |
Other Details:
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Languages: eng Pagination: 29-37 Citation Subset: IM |
Affiliation:
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The Advanced Centre for Biochemical Engineering, Dept of Biochemical Engineering, University College London, London, UK WC1E 7JE. g.lye@ucl.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Automation Bicyclo Compounds / analysis, metabolism* Bioreactors* Biotechnology / methods* Catalysis Fermentation Kinetics Models, Chemical Oxygen / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Bicyclo Compounds; 0/bicyclo(3,2,0)hept-2-en-6-one; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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