| Accelerated cortical atrophy in cognitively normal elderly with high β-amyloid deposition. | |
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MedLine Citation:
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PMID: 22302548 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:Given the recent and growing interest in the concepts of prodromal and presymptomatic Alzheimer disease, it is crucial to determine whether the presence of β-amyloid (Aβ) in the brain of asymptomatic elderly individuals is a pathologic condition associated with accelerated neuronal and synaptic loss. The aim of the present study was to assess whether Aβ influences the rate of atrophy in cognitively normal elderly individuals. METHODS:Seventy-four healthy elderly individuals underwent an MRI scan and a (11)C-Pittsburgh compound B (PiB) PET scan at baseline and a second MRI scan 18 months later. Voxel-wise analyses were performed using maps of annual rate of atrophy generated from the serial MRI scans, including comparison between individuals with high vs low neocortical PiB and correlation with baseline neocortical PiB. RESULTS:The rate of atrophy was significantly higher in the normal elderly individuals with high PiB compared with those with low PiB and was significantly correlated with baseline neocortical PiB, with the highest significance in the temporal neocortex and the posterior cingulate cortex. CONCLUSIONS:Our findings show that the presence of Aβ in the brain, known to occur in about one-third of asymptomatic elderly individuals, is actually a pathologic state associated with accelerated atrophy. They also suggest that therapy aimed to reduce the neurodegenerative process should be commenced in presymptomatic individuals with high PiB. |
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Authors:
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G Chételat; V L Villemagne; N Villain; G Jones; K A Ellis; D Ames; R N Martins; C L Masters; C C Rowe; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-2-1 |
Journal Detail:
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Title: Neurology Volume: - ISSN: 1526-632X ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-2-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Departments of Nuclear Medicine and Centre for PET (G.C., V.L.V., G.J., C.C.R.) and Department of Medicine (V.L.V., C.L.M.), Austin Health, Melbourne, Australia; Inserm-EPHE-Université de Caen/Basse-Normandie (G.C., N.V.), Unité U923, GIP Cyceron, CHU Côte de Nacre, Caen, France; The Mental Health Research Institute (V.L.V., C.L.M.), University of Melbourne, Melbourne, Australia; Academic Unit for Psychiatry of Old Age, Department of Psychiatry (K.A.E.), The University of Melbourne, St. Vincent's Aged Psychiatry Service, St George's Hospital, Melbourne, Australia; National Ageing Research Institute (D.A.), Melbourne, Australia; and Centre of Excellence for Alzheimer's Disease Research & Care (R.N.M.), School of Exercise Biomedical and Health Sciences, Edith Cowan University, Joondalup, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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