| Accelerated coronary artery disease after heart transplantation: the role of enhanced platelet aggregation and thrombosis. | |
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MedLine Citation:
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PMID: 8463767 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study is a prospective examination of the relationship between platelet aggregation and the occurrence of graft failure in a single cohort of heart transplantation (HT) recipients. One-hundred-and-twenty-four patients underwent platelet function study and were then followed for 1 to 24 months (mean 6.7 months). There were nine re-transplantations and 13 deaths (11 related to ischaemic events, and two others). In 15 patients, pathologic examination confirmed or revealed that recent acute myocardial infarction was the obvious cause of the graft failure. In five patients, myocardial fibrosis related to severe and diffuse coronary disease was the only microscopic finding. In the last two patients, the cause of the heart failure was not clearly identified. In recent myocardial infarction there was a high incidence (14/15) of coronary thrombi. Thrombi were multiple, disseminated in the coronary tree end of different age. Their presence at autopsy or after explantation was associated with an enhanced ex vivo platelet aggregability as compared with patients without coronary thrombi (n = 8): 43.3 +/- 1.7% of maximal aggregation vs. 34.4 +/- 2.4 (P = 0.006) and 48.4 +/- 5.2 vs. 22.6 +/- 4.9 (P = 0.003) for the primary and secondary waves of ADP-induced aggregation. These results suggest that thrombosis and platelets may play a major role in the process of accelerated coronary artery disease after HT. |
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Authors:
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M de Lorgeril; R Loire; J Guidollet; P Boissonnat; G Dureau; S Renaud |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of internal medicine Volume: 233 ISSN: 0954-6820 ISO Abbreviation: J. Intern. Med. Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-05-06 Completed Date: 1993-05-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8904841 Medline TA: J Intern Med Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 343-50 Citation Subset: IM |
Affiliation:
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INSERM, Lyon, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Chi-Square Distribution Coronary Disease / blood, etiology*, pathology Coronary Thrombosis / complications, etiology* Female Heart Transplantation / adverse effects*, physiology Humans Male Middle Aged Platelet Aggregation / physiology* Prospective Studies |
| Comments/Corrections | |
Comment In:
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J Intern Med. 1993 Oct;234(4):433-5
[PMID:
8409843
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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