Document Detail

Accelerated coronary artery disease after heart transplantation: the role of enhanced platelet aggregation and thrombosis.
MedLine Citation:
PMID:  8463767     Owner:  NLM     Status:  MEDLINE    
The present study is a prospective examination of the relationship between platelet aggregation and the occurrence of graft failure in a single cohort of heart transplantation (HT) recipients. One-hundred-and-twenty-four patients underwent platelet function study and were then followed for 1 to 24 months (mean 6.7 months). There were nine re-transplantations and 13 deaths (11 related to ischaemic events, and two others). In 15 patients, pathologic examination confirmed or revealed that recent acute myocardial infarction was the obvious cause of the graft failure. In five patients, myocardial fibrosis related to severe and diffuse coronary disease was the only microscopic finding. In the last two patients, the cause of the heart failure was not clearly identified. In recent myocardial infarction there was a high incidence (14/15) of coronary thrombi. Thrombi were multiple, disseminated in the coronary tree end of different age. Their presence at autopsy or after explantation was associated with an enhanced ex vivo platelet aggregability as compared with patients without coronary thrombi (n = 8): 43.3 +/- 1.7% of maximal aggregation vs. 34.4 +/- 2.4 (P = 0.006) and 48.4 +/- 5.2 vs. 22.6 +/- 4.9 (P = 0.003) for the primary and secondary waves of ADP-induced aggregation. These results suggest that thrombosis and platelets may play a major role in the process of accelerated coronary artery disease after HT.
M de Lorgeril; R Loire; J Guidollet; P Boissonnat; G Dureau; S Renaud
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of internal medicine     Volume:  233     ISSN:  0954-6820     ISO Abbreviation:  J. Intern. Med.     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-05-06     Completed Date:  1993-05-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  343-50     Citation Subset:  IM    
INSERM, Lyon, France.
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MeSH Terms
Chi-Square Distribution
Coronary Disease / blood,  etiology*,  pathology
Coronary Thrombosis / complications,  etiology*
Heart Transplantation / adverse effects*,  physiology
Middle Aged
Platelet Aggregation / physiology*
Prospective Studies
Comment In:
J Intern Med. 1993 Oct;234(4):433-5   [PMID:  8409843 ]

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