| Accelerated clearance of plasma triglycerides and free fatty acids in omega3-depleted rats. | |
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MedLine Citation:
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PMID: 17447169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study aims mainly at exploring the effects of a severe depletion in polyunsaturated long-chain omega3 fatty acids upon the fate of circulating lipids. The plasma concentration and fatty acid pattern of triglycerides, diglycerides, free fatty acids, and phospholipids were measured in omega3-depleted and control rats injected intravenously one hour before sacrifice with either saline, a control medium-chain triglyceride:olive oil emulsion or a medium-chain triglyceride:fish oil emulsion recently found to rapidly increase the phospholipid content of C20:5omega3 and C22:6omega3 in different cell types. The estimated fractional removal rate of the injected triglycerides and the clearance of free fatty acids from circulation were both higher in omega3-depleted rats than in control animals. The injection of the lipid emulsions apparently inhibited intracellular lipolysis, this being least pronounced in omega3-depleted rats. The increased clearance of circulating triglycerides and unesterified fatty acids in omega3-depleted rats may favor the cellular accumulation of lipids. In turn, such an accumulation and the lesser regulatory inhibition of tissular lipolysis may match the increased clearance of circulating unesterified fatty acids and, hence, account for the lack of any significant difference in plasma unesterified fatty acid concentration between these and control animals. |
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Authors:
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Y A Carpentier; S Peltier; L Portois; J-M Chardigny; J-L Sébédio; X Leverve; W J Malaisse |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 39 ISSN: 0018-5043 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-20 Completed Date: 2007-06-20 Revised Date: 2009-02-19 |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 295-305 Citation Subset: IM |
Affiliation:
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Laboratoire de Chirurgie Expérimentale, Université Libre de Bruxelles, Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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drug effects,
metabolism Animals Diglycerides / blood Fat Emulsions, Intravenous / pharmacology Fatty Acids, Nonesterified / blood* Fatty Acids, Omega-3 / physiology* Female Male Monoglycerides / blood Phospholipids / blood Rats Rats, Wistar Triglycerides / blood* |
| Chemical | |
Reg. No./Substance:
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0/Diglycerides; 0/Fat Emulsions, Intravenous; 0/Fatty Acids, Nonesterified; 0/Fatty Acids, Omega-3; 0/Monoglycerides; 0/Phospholipids; 0/Triglycerides |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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