Document Detail


Acarbose reduces myocardial infarct size by preventing postprandial hyperglycemia and hydroxyl radical production and opening mitochondrial KATP channels in rabbits.
MedLine Citation:
PMID:  19487955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Acarbose, an antidiabetic drug, is an alpha-glucosidase inhibitor that can inhibit glucose absorption in the intestine. A recent large-scale clinical trial, STOP-NIDDM, showed that acarbose reduces the risk of myocardial infarction. We examined whether acarbose reduces myocardial infarct size and investigated its mechanisms. METHODS AND RESULTS: Rabbits were fed with 1 of 2 diets in this study: normal chow, 30 mg acarbose per 100 g chow for 7 days. Rabbits were assigned randomly to 1 of 4 groups: control (n = 10), acarbose (n = 10), acarbose + 5HD (n = 10, intravenous 5 mg/kg of 5-hydroxydecanoate), and 5HD (n = 10, intravenous 5 mg/kg of 5HD). Rabbits then underwent 30 minutes of coronary occlusion followed by 48-hour reperfusion. Postprandial blood glucose levels were higher in the control group than in the acarbose group. The infarct size as a percentage of the left ventricular area at risk was reduced significantly in the acarbose (19.4% +/- 2.3%) compared with the control groups (42.8% +/- 5.4%). The infarct size-reducing effect of acarbose was abolished by 5HD (43.4% +/- 4.7%). Myocardial interstitial 2,5-dihydroxybenzoic acid levels, an indicator of hydroxyl radicals, increased during reperfusion after 30 minutes of ischemia, but this increase was inhibited in the acarbose group. This was reversed by 5HD. CONCLUSION: Acarbose reduces myocardial infarct size by opening mitochondrial KATP channels, which may be related to the prevention of postprandial hyperglycemia and hydroxyl radical production.
Authors:
Shinya Minatoguchi; Zengi Zhang; Narentuoya Bao; Hiroyuki Kobayashi; Shinji Yasuda; Masamitsu Iwasa; Syouhei Sumi; Itta Kawamura; Yoshihisa Yamada; Kazuhiko Nishigaki; Genzou Takemura; Takako Fujiwara; Hisayoshi Fujiwara
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  54     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-07-21     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-30     Citation Subset:  IM    
Affiliation:
Second Department of Internal Medicine, Gifu University School of Medicine, Gifu 501-1194, Gifu 500, Japan. minatos@gifu-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Acarbose / therapeutic use*
Animals
Blood Glucose / analysis
Catechols / metabolism
Enzyme Inhibitors / therapeutic use
Gentisates / metabolism
Hydroxybenzoic Acids / metabolism
Hydroxyl Radical / metabolism*
Hyperglycemia / drug therapy*
Male
Myocardial Infarction / drug therapy*
Potassium Channels / metabolism*
Rabbits
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Catechols; 0/Enzyme Inhibitors; 0/Gentisates; 0/Hydroxybenzoic Acids; 0/Potassium Channels; 0/mitochondrial K(ATP) channel; 120-80-9/catechol; 303-38-8/2-pyrocatechuic acid; 3352-57-6/Hydroxyl Radical; 490-79-9/2,5-dihydroxybenzoic acid; 56180-94-0/Acarbose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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