| Acanthosis nigricans. | |
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MedLine Citation:
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PMID: 10212845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acanthosis nigricans is a lesion affecting localized areas of the skin in persons with obesity and/or hyperinsulinemia. Roughening of the skin correlates with histological papilomatosis and the apparent darkening is due to hyperkeratosis. Biochemical mechanisms for developing this hyperplastic lesion are unclear, but likely involve local cutaneous growth factors. Cross sectional surveys of unselected populations have demonstrated that young children have low prevalences of obesity and acanthosis nigricans, but the prevalences of both increase with increasing age until plateaus are reached after the age of ten. Nearly 40% of Native American teenagers have acanthosis nigricans, whereas about 13% of African American, 6% of Hispanic, and less than 1% of white, non-Hispanic children aged 10-19 have clinically apparent acanthosis nigricans. We conclude that the presence of this skin lesion is a clinical surrogate of laboratory-documented hyperinsulinemia. Acanthosis nigricans identifies a subgroup within an ethnic group who have the highest insulin concentration, the most severe insulin resistance, and thus the highest risk for the development of type 2 diabetes. |
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Authors:
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C A Stuart; M S Driscoll; K F Lundquist; C R Gilkison; S Shaheb; M M Smith |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of basic and clinical physiology and pharmacology Volume: 9 ISSN: 0792-6855 ISO Abbreviation: J Basic Clin Physiol Pharmacol Publication Date: 1998 |
Date Detail:
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Created Date: 1999-06-30 Completed Date: 1999-06-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9101750 Medline TA: J Basic Clin Physiol Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 407-18 Citation Subset: IM |
Affiliation:
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Department of Medicine, University of Texas Medical Branch at Galveston, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acanthosis Nigricans
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ethnology*,
etiology,
pathology Adolescent Adult Animals Child Child, Preschool Ethnic Groups* Female Humans Hyperinsulinism / complications Insulin / blood Male Mice Obesity / complications |
| Grant Support | |
ID/Acronym/Agency:
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DK33749/DK/NIDDK NIH HHS; DK47116/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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