| Acanthosis nigricans as an indicator of insulin resistance in Chilean adult population. | |
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MedLine Citation:
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PMID: 22072335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Insulin resistance (IR) is associated with a higher risk of multiple diseases and its early detection would allow to minimize the associated risk; the presence of acanthosis nigricans (AN) it's associated to the presence of IR. OBJECTIVE: To evaluate the sensibility and specificity of AN to diagnose IR in a group of Chilean patients. METHODS: We designed a cross-sectional study and it was included subjects that were attended at the Center for the Attention of Metabolic Diseases at the Faculty of Medicine, University of Chile. Sixty subjects (18-60 years age) were included. It was determined BMI and diagnosed AN and skin phototype; blood samples were taken and calculated the HOMA-IR. The normality of the variables where analyzed by Kolmogorov-Smirnov test. There were used χ² and the diagnostic concordance between AN and IR was determined using the Kappa index and Pearson's correlation. Sensibility, specificity, positive and negative predictive value were calculated and accepted p<0.05. RESULTS: The IR diagnose was 67% and AN was 43%. The major proportion of subjects diagnosed as positive for IR were also positive for AN (84.6%). The sensibility of AN to find IR was an 84% and specificity was 100%. Positive and negative predictive values were 100% and 89% respectively. It was observed a positive association between BMI and HOMA-IR (r=0.674; r²=0.454; p<0.001). CONCLUSION: To detect acanthosis nigricans in Chilean population may be effective for the early diagnose of insulin resistance and, therefore, reduce the associated cost of the late treatment of glucose metabolic disturbances. |
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Authors:
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A C Pinheiro; P Rojas; F Carrasco; P Gómez; N Mayas; I Morales |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Volume: 26 ISSN: 1699-5198 ISO Abbreviation: Nutr Hosp Publication Date: 2011 Sep-Oct |
Date Detail:
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Created Date: 2011-11-10 Completed Date: 2012-03-12 Revised Date: 2012-05-09 |
Medline Journal Info:
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Nlm Unique ID: 9100365 Medline TA: Nutr Hosp Country: Spain |
Other Details:
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Languages: eng Pagination: 940-4 Citation Subset: IM |
Affiliation:
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Department of Nutrition, School of Nutrition and Dietetics, Faculty of Medicine, University of Chile, Santiago, Chile. apinheiro@med.uchile.cl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acanthosis Nigricans
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diagnosis,
physiopathology* Adolescent Adult Anthropometry Body Mass Index Chile Color Cross-Sectional Studies Female Humans Insulin Resistance / physiology* Male Middle Aged Obesity / complications, epidemiology Overweight / complications, epidemiology Predictive Value of Tests Retrospective Studies Skin Physiological Phenomena Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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