Document Detail

Acantholytic epidermolysis bullosa.
MedLine Citation:
PMID:  7741547     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We describe a new variant of inherited epidermolysis bullosa and elucidate the clinical, histologic, and ultrastructural features of this condition. OBSERVATIONS: This form of epidermolysis bullosa displays an autosomal dominant inheritance pattern, is characterized by acral bullae, and histologically demonstrates suprabasal clefting with acantholysis. Ultrastructural findings are nonspecific but reminiscent of those observed in benign familial pemphigus. CONCLUSION: Acantholytic epidermolysis bullosa is a rare but distinct clinicopathologic entity that warrants inclusion in the nosologic classification of epidermolysis bullosa.
M D Hoffman; M G Fleming; R W Pearson
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of dermatology     Volume:  131     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-06-08     Completed Date:  1995-06-08     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586-9     Citation Subset:  AIM; IM    
Department of Dermatology, Rush-Presbyterian-St Luke's Medical Center, Chicago, Ill, USA.
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MeSH Terms
Acantholysis / pathology
Blister / pathology
Diagnosis, Differential
Epidermolysis Bullosa / genetics*,  pathology*
Foot Dermatoses / genetics,  pathology
Genes, Dominant
Hand Dermatoses / genetics,  pathology
Microscopy, Electron
Skin / pathology,  ultrastructure

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