Document Detail


Acantholytic dyskeratotic epidermal nevus: a rare histopathologic feature.
MedLine Citation:
PMID:  11841519     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Epidermal nevus is a congenital malformation of the epidermis consisting of verrucoid scaly plaques on the skin, often in a linear fashion. Different histologic features have been seen and, at times, acantholytic dyskeratosis has been observed. We report a new case of acantholytic dyskeratotic epidermal nevus.
CASE REPORT: A 3-year-old girl presented, since birth, asymptomatic keratotic scaly lesions on the left hemithorax and left arm that followed Blaschko's lines.
HISTOLOGY: Biopsies revealed acanthosis, papillomatosis, hyperkeratosis and focal areas of suprabasal clefting with acantholysis, as well as individual dyskeratotic cells (corps ronds et grains) in the upper layers of the epidermis. In the literature, this histologic feature has been reported twice. Generalized or localized Darier's disease are well-established clinical entities with characteristic histologic features of acantholytic dyskeratosis. Because of the linear clinical appearance and the onset at birth or early childhood, the lesions should be regarded as epidermal nevi and not linear Darier's disease.
CONCLUSION: We report here an additional case of dyskeratotic epidermal nevus, which is a rare histopathologic feature.
Authors:
J Mazereeuw-Hautier; I Thibaut; J L Bonafé
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous pathology     Volume:  29     ISSN:  0303-6987     ISO Abbreviation:  J. Cutan. Pathol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-02-13     Completed Date:  2002-04-25     Revised Date:  2011-08-25    
Medline Journal Info:
Nlm Unique ID:  0425124     Medline TA:  J Cutan Pathol     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  52-4     Citation Subset:  IM    
Affiliation:
Service de Dermatologie du Professeur Bonafé, Hôpital Rangueil, Toulouse, France. mazereeuw-hautier.j@chu-toulouse.fr
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MeSH Terms
Descriptor/Qualifier:
Acantholysis / pathology*
Child, Preschool
Diagnosis, Differential
Female
Hamartoma / pathology
Humans
Nevus / pathology*
Skin Diseases / pathology
Skin Neoplasms / pathology*

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