Document Detail

Acanthamoeba keratitis associated with contact lenses: six consecutive cases of successful management.
MedLine Citation:
PMID:  2540794     Owner:  NLM     Status:  MEDLINE    
We examined and treated six patients with acanthamoeba keratitis associated with contact lens wear from 1981 to 1988. Five patients were treated with topical neomycin-polymyxin B-gramicidin (Neosporin) and propamidine isethionate (Brolene) drops. The patients were followed up for an average of 32 months (range 16-75 months). Two patients underwent penetrating keratoplasty at 22 and 26 months after the onset of symptoms and have maintained clear grafts with no evidence of recurrence. In four patients corneal infiltrates cleared on topical medication. All six patients have 6/6 best corrected vision. Early diagnosis and medical treatment alone can result in resolution of corneal infiltrates due to acanthamoebae. With this initial therapy we have had no treatment failures.
M B Moore; J P McCulley
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of ophthalmology     Volume:  73     ISSN:  0007-1161     ISO Abbreviation:  Br J Ophthalmol     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-06-16     Completed Date:  1989-06-16     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0421041     Medline TA:  Br J Ophthalmol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  271-5     Citation Subset:  IM    
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235-9057.
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MeSH Terms
Amebiasis / drug therapy*,  etiology
Amidines / therapeutic use*
Anti-Infective Agents, Local / therapeutic use
Antiprotozoal Agents / therapeutic use
Bacitracin / therapeutic use*
Benzamidines / therapeutic use*
Contact Lenses / adverse effects*
Drug Combinations
Drug Therapy, Combination / therapeutic use
Keratitis / drug therapy*,  etiology
Neomycin / therapeutic use*
Polymyxin B / therapeutic use*
Polymyxins / therapeutic use*
Reg. No./Substance:
0/Amidines; 0/Anti-Infective Agents, Local; 0/Antiprotozoal Agents; 0/Benzamidines; 0/Drug Combinations; 0/Polymyxins; 140-63-6/propamidine isethionate; 1404-04-2/Neomycin; 1404-26-8/Polymyxin B; 1405-87-4/Bacitracin; 8057-37-2/bacitracin zinc, neomycin sulfate, polymyxin B, drug combination

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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