| Acanthamoeba culbertsoni elicits soluble factors that exert anti-microglial cell activity. | |
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MedLine Citation:
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PMID: 20605979 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acanthamoeba culbertsoni is an opportunistic pathogen that causes granulomatous amoebic encephalitis (GAE), a chronic and often fatal disease of the central nervous system (CNS). A hallmark of GAE is the formation of granulomas around the amoebae. These cellular aggregates consist of microglia, macrophages, lymphocytes, and neutrophils, which produce a myriad of proinflammatory soluble factors. In the present study, it is demonstrated that A. culbertsoni secretes serine peptidases that degrade chemokines and cytokines produced by a mouse microglial cell line (BV-2 cells). Furthermore, soluble factors present in cocultures of A. culbertsoni and BV-2 cells, as well as in cocultures of A. culbertsoni and primary neonatal rat cerebral cortex microglia, induced apoptosis of these macrophage-like cells. Collectively, the results indicate that A. culbertsoni can apply a multiplicity of cell contact-independent modes to target macrophage-like cells that exert antiamoeba activities in the CNS. |
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Authors:
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Jenica L Harrison; Gabriela A Ferreira; Erinn S Raborn; Audrey D Lafrenaye; Francine Marciano-Cabral; Guy A Cabral |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-07-06 |
Journal Detail:
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Title: Infection and immunity Volume: 78 ISSN: 1098-5522 ISO Abbreviation: Infect. Immun. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-18 Completed Date: 2010-09-13 Revised Date: 2011-07-25 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: United States |
Other Details:
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Languages: eng Pagination: 4001-11 Citation Subset: IM |
Affiliation:
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Department of Microbiology and Immunology, Virginia Commonwealth University, School of Medicine, 1101 E. Marshall Street, Richmond, VA 23298-0678, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acanthamoeba
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pathogenicity* Animals Apoptosis Brain / immunology Cell Line Chemokines / genetics, metabolism Cytokines / genetics, metabolism Immune Evasion* Mice Microglia / immunology* RNA, Messenger / analysis Rats Serine Proteases / physiology, secretion |
| Grant Support | |
ID/Acronym/Agency:
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5P30NS047463-02/NS/NINDS NIH HHS; DA005832/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Chemokines; 0/Cytokines; 0/RNA, Messenger; EC 3.4.-/Serine Proteases |
| Comments/Corrections | |
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