Document Detail


Acacia honey and chrysin reduce proliferation of melanoma cells through alterations in cell cycle progression.
MedLine Citation:
PMID:  20811719     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Honey has long been used in medicine for different purposes. Only recently, however, its antioxidant property and preventive effects against different diseases, such as cancer, have been highlighted. Chrysin (5,7-dihydroxyflavone) is a natural flavone commonly found in acacia honey. It has previously been shown to be an anti-tumor agent. In this study, we investigated the antiproliferative role of honey or chrysin on human (A375) and murine (B16-F1) melanoma cell lines. The results of the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay and the trypan blue exclusion test showed that both the tested compounds were able to induce an antiproliferative effect on melanoma cells in a dose- and time-dependent manner. Flow cytometry analysis indicated that cytotoxicity induced by honey or chrysin was mediated by G(0)/G(1) cell cycle arrest and induction of hyperploid progression. Our results suggest that the anti-proliferative effects of honey are due mainly to the presence of chrysin. Chrysin may therefore be considered a potential candidate for both cancer prevention and treatment. Further investigation is needed to validate the contribution of chrysin in tumor therapy in vivo.
Authors:
Elena Pichichero; Rosella Cicconi; Maurizio Mattei; Marco Gallinella Muzi; Antonella Canini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of oncology     Volume:  37     ISSN:  1791-2423     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-02     Completed Date:  2010-12-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  973-81     Citation Subset:  IM    
Affiliation:
Department of Biology, Honey Research Center, University of Rome 'Tor Vergata' Via della Ricerca Scientifica 1, I-00133 Rome, Italy.
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MeSH Terms
Descriptor/Qualifier:
Acacia*
Animals
Antineoplastic Agents / pharmacology*
Cell Cycle / drug effects*
Cell Line, Tumor
Cell Proliferation / drug effects*
Dose-Response Relationship, Drug
Energy Metabolism / drug effects
Flavonoids / pharmacology*
Honey*
Humans
Melanoma / metabolism,  pathology*
Melanoma, Experimental / pathology
Mice
Time Factors
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Flavonoids; 480-40-0/chrysin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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