Document Detail


Acacetin-induced cell cycle arrest and apoptosis in human non-small cell lung cancer A549 cells.
MedLine Citation:
PMID:  15246561     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we examined acacetin (5,7-dihydroxy-4'-methoxyflavone), a flavonoid compound, for its effect on proliferation in human non-small cell lung cancer A549 cells. The results first reported that acacetin not only inhibited A549 cell proliferation but also induced apoptosis and blocked cell cycle progression in the G1 phase. ELISA assay demonstrated that acacetin significantly increased the expression of p53 and p21/WAF1 protein, which caused cell cycle arrest. An enhancement in Fas and its two forms of ligands, membrane-bound Fas ligand (mFasL) and soluble Fas ligand (sFasL), might be responsible for the apoptotic effect induced by acacetin. Taken together, p53 and Fas/FasL apoptotic system may participate in the antiproliferative activity of acacetin in A549 cells.
Authors:
Ya-Ling Hsu; Po-Lin Kuo; Chi-Feng Liu; Chun-Ching Lin
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer letters     Volume:  212     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-12     Completed Date:  2004-09-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  53-60     Citation Subset:  IM    
Affiliation:
Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, No. 100, Shin-Chuan 1st Road, Kaohsiung 807, Taiwan, ROC.
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MeSH Terms
Descriptor/Qualifier:
Antigens, CD95
Antigens, Surface
Apoptosis / drug effects*
Carcinoma, Non-Small-Cell Lung / pathology*
Cell Cycle / drug effects*
Cell Division / drug effects
Cyclin-Dependent Kinase Inhibitor p21
Cyclins / biosynthesis
Enzyme-Linked Immunosorbent Assay
Fas Ligand Protein
Flavones*
Flavonoids / pharmacology*
Humans
Lung Neoplasms / pathology*
Membrane Glycoproteins / pharmacology
Tumor Cells, Cultured
Tumor Suppressor Protein p53 / biosynthesis
Chemical
Reg. No./Substance:
0/Antigens, CD95; 0/Antigens, Surface; 0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Cyclins; 0/FASLG protein, human; 0/Fas Ligand Protein; 0/Flavones; 0/Flavonoids; 0/Membrane Glycoproteins; 0/Tumor Suppressor Protein p53; 480-44-4/acacetin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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