Document Detail


Abyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032.
MedLine Citation:
PMID:  15217192     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A screening method was established to detect inhibitors of the biosynthetic pathways of aromatic amino acids and para-aminobenzoic acid, the precursor of folic acid, using an agar plate diffusion assay modified as an antagonism test. By this screening method, a family of three novel polycyclic polyketides named as abyssomicins was isolated from a marine strain of Verrucosispora. The main component abyssomicin C inhibits the pathway between chorismate and para-aminobenzoic acid and is strongly active against gram-positive bacteria, including multi-resistant clinical isolates of Staphylococcus aureus.
Authors:
Julia Riedlinger; Andreas Reicke; Hans Zähner; Bernhard Krismer; Alan T Bull; Luis A Maldonado; Alan C Ward; Michael Goodfellow; Bojan Bister; Daniel Bischoff; Roderich D Süssmuth; Hans-Peter Fiedler
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  57     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-06-25     Completed Date:  2004-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  271-9     Citation Subset:  IM    
Affiliation:
Mikrobiologisches Institut, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany.
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MeSH Terms
Descriptor/Qualifier:
4-Aminobenzoic Acid / antagonists & inhibitors*,  metabolism
Actinobacteria / chemistry,  metabolism*
Amino Acids, Aromatic / antagonists & inhibitors,  metabolism
Anti-Bacterial Agents / chemistry,  isolation & purification*,  pharmacology
Chromatography, High Pressure Liquid
Fermentation
Geologic Sediments / microbiology
Macrolides / isolation & purification*,  pharmacology
Microbial Sensitivity Tests
Molecular Structure
Phylogeny
Chemical
Reg. No./Substance:
0/Amino Acids, Aromatic; 0/Anti-Bacterial Agents; 0/Macrolides; 150-13-0/4-Aminobenzoic Acid

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