| Abuse and therapeutic potential of gamma-hydroxybutyric acid. | |
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MedLine Citation:
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PMID: 10869868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gamma-hydroxbutyric acid is a compound found in mammalian brain that is structurally related to the neurotransmitters gamma-aminobutyric acid and glutamic acid. Gamma-hydroxybutyric acid effects dopaminergic systems in the brain and may be a neurotransmitter. Gamma-hydroxybutyric acid was first reported as a drug of abuse in 1990 and continues to be abused by bodybuilders, participants of "rave" dance parties, and polydrug abusers. Physical dependence can develop after prolonged, high-dose use, and overdoses have been widely reported. Its use in sexual assaults as a "date rape" drug and availability on the internet have recently emerged. Gamma-hydroxybutyric acid has established efficacy as an anesthetic agent, and preliminary evidence supports its utility in the treatment of alcohol dependence, opiate dependence, and narcolepsy. |
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Authors:
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G P Galloway; S L Frederick-Osborne; R Seymour; S E Contini; D E Smith |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Alcohol (Fayetteville, N.Y.) Volume: 20 ISSN: 0741-8329 ISO Abbreviation: Alcohol Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-08-11 Completed Date: 2000-08-11 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8502311 Medline TA: Alcohol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 263-9 Citation Subset: IM |
Affiliation:
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Drug Detoxification, Rehabilitation, and Aftercare Program, Haight-Ashbury Free Clinics, 603 Clayton Street, 94117, San Francisco, CA 94117, USA. gantt@itsa.ucsf.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alcoholism
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drug therapy Animals Brain / drug effects Humans Hydroxybutyrates / adverse effects*, pharmacology, therapeutic use* Substance Withdrawal Syndrome / drug therapy Substance-Related Disorders* |
| Chemical | |
Reg. No./Substance:
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0/Hydroxybutyrates; 591-81-1/4-hydroxybutyric acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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