Document Detail

Abundance of plasma cells in a case of lipodermatosclerosis.
MedLine Citation:
PMID:  20361885     Owner:  NLM     Status:  MEDLINE    
Plasma cells have been considered as an important morphological clue in the diagnosis of some sclerosing cutaneous diseases such as morphea, so much so that humoral immunology has been suggested to have a role in the pathogenesis of such diseases. Nevertheless, they are hardly ever described as a prominent feature in lipodermatosclerosis in which granulocytes have been claimed as the main pathogenic cell. We report a case of lipodermatosclerosis in a 77-year-old woman, in which plasma cells were abundant in the thickened fibrous septa of the hypodermis. They were highlighted on immunohistochemical study with CD79a, CD138 and EMA, and showed polyclonal immunoexpression of kappa and lambda immunoglobulin light chains.
Angel Fernandez-Flores; Jose A Manjón
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Acta dermatovenerologica Croatica : ADC     Volume:  18     ISSN:  1847-6538     ISO Abbreviation:  Acta Dermatovenerol Croat     Publication Date:  2010  
Date Detail:
Created Date:  2010-04-05     Completed Date:  2010-07-15     Revised Date:  2012-08-31    
Medline Journal Info:
Nlm Unique ID:  9433781     Medline TA:  Acta Dermatovenerol Croat     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  27-31     Citation Subset:  IM    
Service of Anatomic Pathology, Clinica Ponferrada, Avenida Galicia 1, 24400 Ponferrada, Spain.
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MeSH Terms
Diagnosis, Differential
Leg Dermatoses / pathology*
Panniculitis / pathology*
Plasma Cells / pathology*
Scleroderma, Localized / pathology*

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