Document Detail

Absorption spectroscopy in microfluidic flow cells using a metal clad leaky waveguide device with a porous gel waveguide layer.
MedLine Citation:
PMID:  23152951     Owner:  NLM     Status:  Publisher    
Broadband absorption spectroscopy is advantageous because the full spectral profile of an analyte can permit identification of species. This work for the first time investigates the feasibility of a metal clad leaky waveguide (MCLW) device to obtain an absorption spectrum of an analyte of interest, methylene blue, using a white light source in a microfluidic flow cell. The MCLW device comprises a porous low refractive index gel, agarose, deposited on a titanium coated glass slide. The device was capable of detecting 2.3 μM of methylene blue at a wavelength of 650 nm. The corresponding minimum detectable absorbance is 1.6 × 10(-1) cm(-1). In comparison to commonly used detection devices the MCLW is simpler, robust, easier to fabricate and can be easily interfaced to microfluidic devices. It was also possible to store the MCLW devices dry for up to a year and rehydrate them in 30 s to a working condition.
Ruchi Gupta; Behnam Bastani; N J Goddard; Bruce Grieve
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-14
Journal Detail:
Title:  The Analyst     Volume:  -     ISSN:  1364-5528     ISO Abbreviation:  Analyst     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372652     Medline TA:  Analyst     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
School of Chemical Engineering and Analytical Science, University of Manchester, Manchester, UK.
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