Document Detail


Absorption of quinidine and dihydroquinidine in humans.
MedLine Citation:
PMID:  7318878     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Quinidine and dihydroquinidine were administered as the sulphates in an oral solution to seven healthy volunteers. In all subjects, dihydroquinidine was absorbed to a lesser extent than quinidine. On the basis of comparative AUC pu to 6 h after administration, dihydroquinidine was 73% as available as quinidine. Rates of elimination of the compounds were similar. No correlation could be found between saliva and plasma levels for either compound. Limits for content of dihydroquinidine in commercial quinidine preparations seem essential to ensure adequate bioavailability.
Authors:
D M Hailey; A R Lea; D M Coles; P E Heaume; W J Smith
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  21     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1981  
Date Detail:
Created Date:  1982-03-22     Completed Date:  1982-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  195-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Drug Combinations
Female
Humans
Male
Quinidine / administration & dosage,  analogs & derivatives*,  blood,  metabolism*
Saliva / analysis
Time Factors
Chemical
Reg. No./Substance:
0/Drug Combinations; 1435-55-8/hydroquinidine; 56-54-2/Quinidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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