Document Detail

Absorption of oral neomycin in premature infants with suspected necrotizing enterocolitis.
MedLine Citation:
PMID:  7151637     Owner:  NLM     Status:  MEDLINE    
The oral absorption of neomycin was studied in 2 premature infants (32 weeks of gestation) with suspected necrotizing enterocolitis. 1 infant received 50 mg and the other 100 mg of neomycin sulfate/kg/day in 4 divided doses for approximately 7 days. Plasma neomycin levels were determined by a micro, sensitive and specific high-performance liquid chromatographic assay developed in our laboratory. Plasma levels as high as 2.9 and 4.5 micrograms/ml were observed in these 2 infants. A urinary recovery study for 1 infant revealed that at least 3.7% of the oral dose was absorbed. The significant and persistent plasma levels of neomycin in these patients suggest the need for extreme caution in using this potentially toxic antibiotic for prolonged treatment in neonates.
R L Nation; S M Huang; D Vidyasagar; M Reed; W L Chiou
Related Documents :
3740907 - Renal handling of phosphate in the first six months of life.
19460127 - Exposure to furosemide as the strongest risk factor for nephrocalcinosis in preterm inf...
3279177 - Ontogeny of glucose homeostasis in low birth weight infants.
1567237 - Illness and excretion of organophosphate metabolites four months after household pest e...
23359527 - Colistin inhalation monotherapy for ventilator-associated pneumonia of acinetobacter ba...
21357337 - A case of severe eosinophilia in a preterm infant.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  5     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1982  
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  53-60     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Chromatography, High Pressure Liquid / methods
Creatinine / blood
Enterocolitis, Pseudomembranous / drug therapy,  metabolism*
Infant, Newborn
Infant, Premature, Diseases / drug therapy,  metabolism*
Intestinal Absorption
Neomycin / metabolism*,  therapeutic use
Time Factors
Reg. No./Substance:
1404-04-2/Neomycin; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Serum concentrations of gentamicin following oral administration to preterm newborns.
Next Document:  Cardiovascular birth defects and antenatal exposure to female sex hormones.