Document Detail


Absorption of oral neomycin in premature infants with suspected necrotizing enterocolitis.
MedLine Citation:
PMID:  7151637     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The oral absorption of neomycin was studied in 2 premature infants (32 weeks of gestation) with suspected necrotizing enterocolitis. 1 infant received 50 mg and the other 100 mg of neomycin sulfate/kg/day in 4 divided doses for approximately 7 days. Plasma neomycin levels were determined by a micro, sensitive and specific high-performance liquid chromatographic assay developed in our laboratory. Plasma levels as high as 2.9 and 4.5 micrograms/ml were observed in these 2 infants. A urinary recovery study for 1 infant revealed that at least 3.7% of the oral dose was absorbed. The significant and persistent plasma levels of neomycin in these patients suggest the need for extreme caution in using this potentially toxic antibiotic for prolonged treatment in neonates.
Authors:
R L Nation; S M Huang; D Vidyasagar; M Reed; W L Chiou
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  5     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1982  
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  53-60     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid / methods
Creatinine / blood
Enterocolitis, Pseudomembranous / drug therapy,  metabolism*
Female
Humans
Infant, Newborn
Infant, Premature, Diseases / drug therapy,  metabolism*
Intestinal Absorption
Neomycin / metabolism*,  therapeutic use
Time Factors
Chemical
Reg. No./Substance:
1404-04-2/Neomycin; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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