| Absorption of oleic and palmitic acids from emulsions and micellar solutions. | |
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MedLine Citation:
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PMID: 5645848 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A lipid mixture (monoolein, oleic acid-1-(14)C, and palmitic acid-9,10-(3)H) was infused intraduodenally at a steady rate for 8 hr in fasted, unanesthetized rats. The same dose of lipid was given together with pure conjugated bile salts either as an emulsion, 2.5 mM bile salts, or as a micellar solution, 10 mM bile salts. The emulsion contained very little or no micellar lipid. Thoracic duct lymph was collected and in some experiments bile and pancreatic juice were drained to the exterior. After 4-5 hr infusion the same steady lymphatic output of radioactive fatty acids was obtained with emulsion as with micellar solution. It was concluded that absorption of fatty acid could proceed efficiently in the virtual absence of micellar solubilization. In rats with biliary plus pancreatic fistulae, labeled triglyceride was absorbed poorly relative to free fatty acids in the same emulsified particles. This suggested that fatty acids were transferred to the absorptive cells in monomolecular solution and not as emulsion particles. Substitution of a synthetic nonionic detergent for bile salts in lipid mixtures given to rats with biliary and pancreatic fistulae did not affect the lymphatic output of radioactive fatty acids. This indicated that mucosal esterification of labeled free fatty acids was normal in the absence of bile salts. The physical state of the lipid did not affect the pathway of absorption. Finally, comparison of the increased output of esterified fat in the lymph with the output of labeled fat suggested that fat absorption did not greatly affect the turnover of endogenous, unlabeled fat. Results were consistent with the view that most of the endogenous lymph fat comes from reabsorbed biliary lipid. |
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Authors:
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W J Simmonds; T G Redgrave; R L Willix |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 47 ISSN: 0021-9738 ISO Abbreviation: J. Clin. Invest. Publication Date: 1968 May |
Date Detail:
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Created Date: 1968-06-03 Completed Date: 1968-06-03 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1015-25 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / physiology* Emulsions Fatty Acids Intestinal Absorption / physiology* Lymph / physiology* Male Oleic Acids* Palmitic Acids* Rats |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Emulsions; 0/Fatty Acids; 0/Oleic Acids; 0/Palmitic Acids |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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