| Absorption of nutrients is only slightly reduced by supplementing enteral formulas with viscous fiber in miniature pigs. | |
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MedLine Citation:
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PMID: 9868193 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Viscous polysaccharides reduce intestinal absorption of glucose and diminish postprandial hyperglycemia. However, it is unknown whether viscous fiber also inhibits absorption of nutrients under conditions of enteric feeding. Therefore, we measured the absorption rates of nutrients in miniature pigs by perfusing a 150-cm length of jejunum with 8.37 kJ/min of the three following enteral diets: an isoosmotic oligomeric diet (1670 kJ/L), a hyperosmotic oligomeric diet and an isoosmotic polymeric diet (both 3350 kJ/L). The diets were supplemented with guar gum from 0 to 4.4 g/L. With the three guar-free diets, the mean absorption rate of energy was 5.2 +/- 0.32 kJ/min, corresponding to 62% of the energy infused. Absorption rates of carbohydrate, protein, fat and energy linearly declined as concentrations of guar or the logarithm of chyme viscosity increased. Due to modulations in viscosity, the inhibitory effects of guar were significantly different among the three diets. With the isoosmotic and hyperosmotic oligomeric and the polymeric diets, the addition of 1 g guar/L diminished the absorption of energy by 9.7, 6. 6 and 3.7%, respectively. The strong inhibitory effect on nutrient absorption with the isoosmotic oligomeric diet was caused by an increase in chyme viscosity due to water absorption. With the hyperosmotic oligomeric and the polymeric diets, the chyme viscosity and thus inhibitory effects on absorption were diminished by water secretion and the concomitant infusion of pancreatic enzymes. Results indicate that the addition of small amounts of guar gum to enteral diets of high energy density exerts only small effects on absorption of nutrients. |
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Authors:
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H Ehrlein; A Stockmann |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutrition Volume: 128 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1998 Dec |
Date Detail:
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Created Date: 1999-01-27 Completed Date: 1999-01-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2446-55 Citation Subset: IM |
Affiliation:
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Institute of Physiology, University of Hohenheim, D 70593 Stuttgart, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Carbohydrates / pharmacokinetics Dietary Fiber / pharmacology* Dose-Response Relationship, Drug Energy Metabolism / drug effects Enteral Nutrition* Female Galactans / administration & dosage, pharmacology* Gastrointestinal Transit / drug effects Intestinal Absorption / drug effects* Jejunum / drug effects*, metabolism Mannans / administration & dosage, pharmacology* Plant Gums Soybeans Swine Swine, Miniature Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Galactans; 0/Mannans; 0/Plant Gums; 9000-30-0/guar gum |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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