Document Detail

Absorption of nicotine and carbon monoxide from passive smoking under natural conditions of exposure.
MedLine Citation:
PMID:  6648864     Owner:  NLM     Status:  MEDLINE    
Seven non-smokers were exposed to tobacco smoke under natural conditions for two hours in a public house. Measures of nicotine and cotinine in plasma, saliva, and urine and expired air carbon monoxide all showed reliable increases. The concentrations of carbon monoxide and nicotine after exposure averaged 15.7% and 7.5% respectively of the values found in heavy smokers. Although the increase in expired air carbon monoxide of 5.9 ppm was similar to increases in smokers after a single cigarette, the amount of nicotine absorbed was between a tenth and a third of the amount taken in from one cigarette. Since this represented a relatively extreme acute natural exposure, any health risks of passive smoking probably depend less on quantitative factors than on qualitative differences between sidestream and mainstream smoke.
M J Jarvis; M A Russell; C Feyerabend
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Thorax     Volume:  38     ISSN:  0040-6376     ISO Abbreviation:  Thorax     Publication Date:  1983 Nov 
Date Detail:
Created Date:  1984-01-26     Completed Date:  1984-01-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0417353     Medline TA:  Thorax     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  829-33     Citation Subset:  IM    
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MeSH Terms
Carbon Monoxide / analysis*
Cotinine / metabolism
Environmental Exposure
Nicotine / metabolism*
Saliva / metabolism
Tobacco Smoke Pollution / analysis*
Reg. No./Substance:
0/Tobacco Smoke Pollution; 486-56-6/Cotinine; 54-11-5/Nicotine; 630-08-0/Carbon Monoxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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