| Absorption of intestinal free cholesterol is lowered by supplementation of Areca catechu L. extract in rats. | |
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MedLine Citation:
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PMID: 12005171 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Areca extracts exhibiting a strong inhibitory activity against pancreatic cholesterol esterase (pCEase) in vitro were previously found to lower the absorption of dietary cholesteryl ester. Therefore, to determine whether a combined Areca extract also affects the absorption of intestinal free cholesterol, male rats were fed a diet containing free cholesterol (1%, w/w) either with or without an Areca nut extract supplement (0.5%, w/w). The Areca extract supplement significantly lowered the plasma cholesterol concentration by 25% without any change in the plasma triglyceride concentration, when compared to the control group. The supplement also significantly lowered the small intestinal pCEase activity by 39.1% compared to that of the control group. As regards the hepatic and intestinal ACAT activities, only the intestinal enzyme activity was significantly lowered by the supplement, when compared to the control group. The absorbed cholesterol that appeared in the blood after an oral dose of [1,2(n)-3H] free cholesterol was significantly lower in the rats supplemented with the Areca nut extract, compared with the control group. These results suggest that the inhibition of intestinal ACAT and possibly pCEase may facilitate the metabolic efficiency of the Areca nut extract as regards the absorption of intestinal free cholesterol. The structure and chemical properties of the active compound in the water-soluble Areca extract remain to be elucidated. |
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Authors:
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Yong Bok Park; Seon-Min Jeon; Sung-June Byun; Hee-Sook Kim; Myung-Sook Choi |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Life sciences Volume: 70 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-05-13 Completed Date: 2002-05-29 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 1849-59 Citation Subset: IM |
Affiliation:
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Department of Genetic Engineering, Kyungpook National University, Taegu, South Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Areca* Cholesterol / metabolism* Enzyme Inhibitors / pharmacology* Intestinal Absorption / drug effects* Male Plant Extracts / pharmacology* Rats Rats, Sprague-Dawley Sterol Esterase / antagonists & inhibitors* Sterol O-Acyltransferase / antagonists & inhibitors* Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Plant Extracts; 0/Triglycerides; 57-88-5/Cholesterol; EC 2.3.1.26/Sterol O-Acyltransferase; EC 3.1.1.-/bile salt-stimulated lipase; EC 3.1.1.13/Sterol Esterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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