Document Detail

Absorption of hexachlorophane from dusting powder on newborn infant's skin.
MedLine Citation:
PMID:  4529485     Owner:  NLM     Status:  MEDLINE    
In a maternity hospital in which the umbilicus and trunk of healthy newborn infants were treated with 0.33% hexachlorophane dusting powder, the hexachlorophane content of blood was measured in mothers before delivery, in infants' umbilical samples at birth, and at 8 days of age in capillary blood samples. One mother and her baby had rather high blood concentrations of hexachlorophane, probably derived from a toilet preparation used before admission to hospital. Hexachlorophane was absent or barely detectable in the other mothers' blood and in the infants' umbilical blood. The hexachlorophane concentrations in the blood of 8-day-old infants ranged from nil to 0.166 mug./ml. (mean 0.066 mug./ml.). These were much less than the concentrations reported to be toxic in animals.In a previous trial now reported here, a dusting powder containing chlorhexidine instead of hexachlorophane was found to delay the separation of the umbilical cord.
W A Gillespie; B D Corner; D Burman; V G Alder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of hygiene     Volume:  73     ISSN:  0022-1724     ISO Abbreviation:  J Hyg (Lond)     Publication Date:  1974 Oct 
Date Detail:
Created Date:  1975-01-10     Completed Date:  1975-01-10     Revised Date:  2010-09-10    
Medline Journal Info:
Nlm Unique ID:  0375374     Medline TA:  J Hyg (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  311-5     Citation Subset:  IM    
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MeSH Terms
Anti-Infective Agents, Local / blood,  toxicity
Biguanides / blood,  toxicity
Chlorobenzenes / blood,  toxicity
Hexachlorophene / blood*,  toxicity
Infant, Newborn*
Skin Absorption
Time Factors
Reg. No./Substance:
0/Anti-Infective Agents, Local; 0/Biguanides; 0/Chlorobenzenes; 0/Powders; 70-30-4/Hexachlorophene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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