Document Detail


Absorption and elimination of alpha-thrombin and tranexamic acid after fibrin sealant application on resected livers in rabbits.
MedLine Citation:
PMID:  9819004     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Maximum blood concentrations (Cmax) of thrombin and tranexamic acid were evaluated in the bloodstream after local application of a radioactively labelled cryoprecipitate based fibrin (CBF) sealant to a partial liver resection in rabbits. The Cmax of 3H-tranexamic acid reached a peak of 0.015 mg/ml of plasma after 1 h and then slowly cleared within 10 h, never reaching pharmacologically active systemic levels, and demonstrating a slow release from the clot and a fast clearance for the drug. The Cmax of 125I-alpha-thrombin never exceeded 56 milliunits of thrombin equivalent per ml, lower than endogenous thrombin generated in abdominal surgery. Furthermore, the low ratio of trichloroacetic acid precipitable counts versus total counts indicates that the majority of thrombin proteins are in a continuous process of degradation into very small peptides, which are known to be biologically inactive. The bioavailability of tranexamic acid, when embedded in a fibrin sealant, is much longer than when intravenously administered. Conversely, the circulating thrombin resulting from the sealant is low-molecular-weight degradation products with probably no significant biological activity.
Authors:
I Nur; L Routledge; G Lushkov; P Paulmier; M Virat
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  9     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-02-26     Completed Date:  1999-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  533-7     Citation Subset:  IM    
Affiliation:
Omrix Biopharmaceuticals S.A., Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Absorption
Animals
Biological Availability
Fibrin Tissue Adhesive / administration & dosage*
Half-Life
Hemostatics / administration & dosage*
Humans
Iodine Radioisotopes
Kinetics
Liver / surgery*
Rabbits
Thrombin / administration & dosage,  pharmacokinetics*
Tranexamic Acid / administration & dosage,  pharmacokinetics*
Tritium
Chemical
Reg. No./Substance:
0/Fibrin Tissue Adhesive; 0/Hemostatics; 0/Iodine Radioisotopes; 10028-17-8/Tritium; 1197-18-8/Tranexamic Acid; EC 3.4.21.5/Thrombin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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