| Absorption and elimination of alpha-thrombin and tranexamic acid after fibrin sealant application on resected livers in rabbits. | |
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MedLine Citation:
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PMID: 9819004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Maximum blood concentrations (Cmax) of thrombin and tranexamic acid were evaluated in the bloodstream after local application of a radioactively labelled cryoprecipitate based fibrin (CBF) sealant to a partial liver resection in rabbits. The Cmax of 3H-tranexamic acid reached a peak of 0.015 mg/ml of plasma after 1 h and then slowly cleared within 10 h, never reaching pharmacologically active systemic levels, and demonstrating a slow release from the clot and a fast clearance for the drug. The Cmax of 125I-alpha-thrombin never exceeded 56 milliunits of thrombin equivalent per ml, lower than endogenous thrombin generated in abdominal surgery. Furthermore, the low ratio of trichloroacetic acid precipitable counts versus total counts indicates that the majority of thrombin proteins are in a continuous process of degradation into very small peptides, which are known to be biologically inactive. The bioavailability of tranexamic acid, when embedded in a fibrin sealant, is much longer than when intravenously administered. Conversely, the circulating thrombin resulting from the sealant is low-molecular-weight degradation products with probably no significant biological activity. |
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Authors:
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I Nur; L Routledge; G Lushkov; P Paulmier; M Virat |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 9 ISSN: 0957-5235 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1999-02-26 Completed Date: 1999-02-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 533-7 Citation Subset: IM |
Affiliation:
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Omrix Biopharmaceuticals S.A., Brussels, Belgium. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Animals Biological Availability Fibrin Tissue Adhesive / administration & dosage* Half-Life Hemostatics / administration & dosage* Humans Iodine Radioisotopes Kinetics Liver / surgery* Rabbits Thrombin / administration & dosage, pharmacokinetics* Tranexamic Acid / administration & dosage, pharmacokinetics* Tritium |
| Chemical | |
Reg. No./Substance:
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0/Fibrin Tissue Adhesive; 0/Hemostatics; 0/Iodine Radioisotopes; 10028-17-8/Tritium; 1197-18-8/Tranexamic Acid; EC 3.4.21.5/Thrombin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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