Document Detail


Absorption and distribution of [1-14C]dolichol intubated into rats.
MedLine Citation:
PMID:  3606856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
[1-14C]Dolichol was mixed in vitro with sunflower seed oil and intubated into rats. Radioactivity began to appear in the blood at 3 h and peaked after about 6 h. The absorbed radioactivity was rapidly cleared from the blood. At 7.5 h postintubation two thirds of the radioactivity in the serum was associated with chylomicrons and about one quarter with the high density lipoproteins. At 12 h the proportion of the radioactivity in the chylomicrons had fallen to one third and that in the high density lipoproteins had increased to one half of the total. Less than 0.02% of the dose was found in the tissues after 12 h. Liver and blood each contained about one third of the total, with smaller amounts in the lungs and spleen. The heart, testes, brain, and kidneys contained only traces of radioactivity. After 12 h most of the radioactivity in the tissues and feces was present as [1-14C]dolichol. The radioactive compounds in the urine (about 0.05% of the dose) were more polar than [1-14C]dolichol as determined by thin-layer chromatography.
Authors:
D C Crick; K K Carroll
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemistry and cell biology = Biochimie et biologie cellulaire     Volume:  65     ISSN:  0829-8211     ISO Abbreviation:  Biochem. Cell Biol.     Publication Date:  1987 Apr 
Date Detail:
Created Date:  1987-09-22     Completed Date:  1987-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8606068     Medline TA:  Biochem Cell Biol     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  317-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Carbon Radioisotopes
Diterpenes / metabolism*
Dolichol / metabolism*
Kinetics
Lipoproteins / blood
Male
Rats
Rats, Inbred Strains
Tissue Distribution
Chemical
Reg. No./Substance:
0/Carbon Radioisotopes; 0/Diterpenes; 0/Lipoproteins; 2067-66-5/Dolichol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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