| Absorption of dietary cholesterol oxidation products and their downstream metabolic effects are reduced by dietary apple polyphenols. | |
| | |
MedLine Citation:
|
PMID: 17393221 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Exogenous and endogenous cholesterol oxidation products (COPs) perturb various metabolic processes, and thereby they may induce various homeostasis-related disorders. Here, we observed that procyanidin-rich dietary apple polyphenol (APP) from unripe apples alleviates the perturbation of lipid metabolism by decreasing the exogenous COP levels in rats. Dietary COPs may be the greatest source of COPs found in the human body. Rats (4 weeks of age) were fed AIN-purified diets containing 0.3% COPs supplemented with 0.5 or 2.5% APP for 3 weeks. Dietary APP alleviated the growth inhibition action of the exogenous COPs. The modulations of the liver lipid profile by COPs remained unchanged. However, serum total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels increased following the intake of dietary APP. Further, dietary APP inhibited the increase in lipid peroxide levels in the liver and serum by COPs. The activity of hepatic Delta6 desaturase was lowered by dietary APP in a dose-dependent manner, although exogenous COPs generally increased the activity of this enzyme. In keeping with this observation, Delta6 desaturation indices in the phospholipids and cholesteryl esters of the liver and serum lipids were lower in the APP-fed groups than those in the control group. Dietary APP also promoted the excretion of exogenous COPs, cholesterol, and acidic steroids in feces. Therefore, the inhibition of intestinal absorption of COPs may partly contribute to the alleviation of the perturbation of lipid metabolism and lipid peroxidation levels. Thus, APP may be an important removal agent of exogenous toxic material such as COPs contained in processed or fast foods. |
| | |
Authors:
|
Yamato Ogino; Kyoichi Osada; Shingo Nakamura; Yutaka Ohta; Tomomasa Kanda; Michihiro Sugano |
Publication Detail:
|
Type: Journal Article Date: 2007-02-10 |
Journal Detail:
|
Title: Lipids Volume: 42 ISSN: 0024-4201 ISO Abbreviation: Lipids Publication Date: 2007 Mar |
Date Detail:
|
Created Date: 2007-03-29 Completed Date: 2007-08-06 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0060450 Medline TA: Lipids Country: United States |
Other Details:
|
Languages: eng Pagination: 151-61 Citation Subset: IM |
Affiliation:
|
Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight / drug effects Cholesterol, Dietary / metabolism, pharmacokinetics* Chromatography, Gas Enzyme Activation / drug effects Erythrocytes / metabolism Feces / chemistry Flavonoids / administration & dosage, chemistry, pharmacology* Intestinal Absorption / drug effects Lipid Metabolism / drug effects Lipid Peroxides / metabolism Lipids / blood Malus / chemistry* Mass Spectrometry Molecular Structure Oxidation-Reduction / drug effects Phenols / administration & dosage, chemistry, pharmacology* Prostaglandins / metabolism Rats Rats, Sprague-Dawley Steroids / metabolism Superoxide Dismutase / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Cholesterol, Dietary; 0/Flavonoids; 0/Lipid Peroxides; 0/Lipids; 0/Phenols; 0/Prostaglandins; 0/Steroids; 0/polyphenols; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Postprandial lipemia is modified by the presence of the APOB-516C/T polymorphism in a healthy Caucas...
Next Document: Intestinal epithelial cells absorb gamma-tocotrienol faster than alpha-tocopherol.