Document Detail


Absorption of cholesterol oxidation products from ordinary foodstuff in humans.
MedLine Citation:
PMID:  9745108     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Information on the absorption of cholesterol oxidation products (COP) from ordinary foodstuff in humans is scarce. METHODS: Five healthy young men were offered a salami- and Parmesan-containing meal naturally rich in COP. Plasma and lipoprotein COP concentrations were measured over the following 9 h. RESULTS: The mean plasma free (nonesterified) COP concentration showed its maximal increase 3 and 5 h after meal consumption. In contrast, the raise in plasma total COP concentration began 6 h after the meal with a maximum at 8 h and was statistically significant for 7alpha- and 7beta-hydroxycholesterol and 7-ketocholesterol. The increase in plasma total cholesterol concentration was comparable to that of total COP. Comparing the COP composition of the chylomicrons and the test meal, cholestanetriol, 7-ketocholesterol, and to a lesser extent cholesterol-alpha-epoxide were underrepresented in the chylomicrons as was the opposite for 7beta-hydroxycholesterol. In very-low-density lipoprotein, a steady increase in the COP:cholesterol ratio was observed from 6 h on. CONCLUSION: COP from ordinary foodstuff were absorbed in the human intestinal tract but differences in the bioavailability of the single COP compounds were found.
Authors:
J Linseisen; G Wolfram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  42     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:  1998  
Date Detail:
Created Date:  1998-11-10     Completed Date:  1998-11-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  221-30     Citation Subset:  IM    
Affiliation:
Institute of Nutrition Science of the Technical University of Munich, Germany. linseise@server.ernwiss.agrar.tu-muenchen.de
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MeSH Terms
Descriptor/Qualifier:
Absorption
Adult
Cheese
Cholesterol / blood,  metabolism,  pharmacokinetics*
Chylomicrons
Food*
Humans
Hydroxycholesterols / pharmacokinetics
Ketocholesterols / pharmacokinetics
Kinetics
Male
Meat Products
Oxidation-Reduction
Chemical
Reg. No./Substance:
0/Chylomicrons; 0/Hydroxycholesterols; 0/Ketocholesterols; 566-26-7/cholest-5-en-3 beta,7 alpha-diol; 566-28-9/7-ketocholesterol; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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