| Absorption of biological amines of bacterial origin in normal and sick infants. | |
| | |
MedLine Citation:
|
PMID: 261524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This investigation aims at monitoring the formation of diamines in the gastrointestinal tract of human infants, and thereby also the bacterial colonization of the intestine, by studying the urinary excretion of the heterocyclic amine piperidine during development and in different malabsorptive states. A gas chromatographic assay of the dinitrophenyl derivative of piperidine and a mass spectrometric method of identification were worked out and applied. The piperidine excretion was expressed in units of urinary creatinine concentration. Adult women show a greater variation than men, both inter- and intra-individually. The piperidine excretion is very low and mostly undetectable in the first week of life. There is an increase in weaning, with a significant difference between breast-fed and formula-fed infants at 4--6 months. There is a significant difference between infants suffering from untreated coeliac disease and infants without malabsorption. The findings indicate that piperidine excretion is a sensitive biochemical index of changes in the gastrointestinal flora. The high excretion in coeliac disease suggests that piperidine, which is known to have nicotine-like synaptic activity in the CNS, is one of the hitherto unidentified 'auto-intoxicating' substances arising from the bacterial decomposition of protein suggested by Metchnikoff in 1903. |
| | |
Authors:
|
B S Lindblad; J Alm; A Lundsjö; J J Rafter |
Related Documents
:
|
23030834 - Cord blood s100b levels in low-risk term pregnancies with meconium stained amnioticfluid. 6786074 - Cysteine supplementation to cysteine-free intravenous feeding regimens in newborn infants. 6395624 - Diuresis and urine concentration during cpap in newborn infants. 945654 - Renal function as a marker of human fetal maturation. 4078664 - Ophthalmoscopic findings in occult child abuse. 22287124 - Effect of ada(1) mother-fetus and wife-husband phenotypic differences on the ratio birt... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Ciba Foundation symposium Volume: - ISSN: 0300-5208 ISO Abbreviation: Ciba Found. Symp. Publication Date: 1979 Jan 16-18 |
Date Detail:
|
Created Date: 1980-06-25 Completed Date: 1980-06-25 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0356636 Medline TA: Ciba Found Symp Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 281-91 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Age Factors Amines / metabolism*, urine Breast Feeding Child, Preschool Female Humans Infant Infant Food Infant, Newborn Infant, Premature Intestinal Absorption* Intestines / microbiology* Male Sex Factors |
| Chemical | |
Reg. No./Substance:
|
0/Amines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The influence of gestational age and size on the absorption of D-xylose and D-glucose from the small...
Next Document: Morphogenesis of the small intestine during fetal development.