Document Detail


Absorption of anthocyanins from blueberries and serum antioxidant status in human subjects.
MedLine Citation:
PMID:  12475297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years, numerous studies have shown that the polyphenolics present in fruit and vegetable products exhibit a wide range of biological effects. However, there is little reliable information on the absorption of glycosylated and acylated anthocyanins in humans. In the present study, the absorption of anthocyanins in humans was investigated after the consumption of a high-fat meal with a freeze-dried blueberry powder containing 25 individual anthocyanins including 6 acylated structures. Nineteen of the 25 anthocyanins present in the blueberries were detected in human blood serum. Furthermore, the appearance of total anthocyanins in the serum was directly correlated with an increase in serum antioxidant capacity (ORAC(acetone), P < 0.01). These results show that anthocyanins can be absorbed in their intact glycosylated and possibly acylated forms in human subjects and that consumption of blueberries, a food source with high in vitro antioxidant properties, is associated with a diet-induced increase in ex vivo serum antioxidant status.
Authors:
G Mazza; Colin D Kay; Tony Cottrell; Bruce J Holub
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  50     ISSN:  0021-8561     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-12-11     Completed Date:  2003-01-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7731-7     Citation Subset:  IM    
Affiliation:
Food Research Program, Pacific Agri-Food Research Centre, Agriculture and Agri-Food Canada, Summerland, British Columbia, Canada. mazzag@agr.gc.ca
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MeSH Terms
Descriptor/Qualifier:
Absorption
Acylation
Anthocyanins / blood,  pharmacokinetics*
Antioxidants / administration & dosage,  analysis*
Blueberry Plant / chemistry*
Chromatography, High Pressure Liquid
Dietary Fats / administration & dosage
Fruit / chemistry*
Glucosides / blood
Glycosylation
Humans
Kinetics
Male
Middle Aged
Chemical
Reg. No./Substance:
0/Anthocyanins; 0/Antioxidants; 0/Dietary Fats; 0/Glucosides; 13270-61-6/delphinidin; 30113-37-2/malvidin 3-galactoside; 7228-78-6/malvidin-3-glucoside

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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