| Absorption of 6-O-Caffeoylsophorose and Its Metabolites in Sprague-Dawley Rats Detected by ECD-HPLC and ESI-TOF-MS Methods. | |
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MedLine Citation:
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PMID: 21534624 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Absorption and metabolism of a natural compound, 6-O-caffeoylsophorose (CS) from acylated anthocyanins in a red vinegar fermented with purple sweetpotato, were clarified. The absorption of CS and conjugated CS in blood from orally administrated Sprague-Dawley rats at a dose of 400 mg/kg was investigated by an electrochemical detector-high performance liquid chromatography. As a result, CS was successfully detected in rat plasma (AUC0-6h: 108.6 ± 8.1 nmol·h/mL) and was found to be an intact absorbable polyphenol. In addition, a half of absorbed CS was detected as its conjugates (AUC0-6h: 50.7 ± 5.7 nmol·h/mL), as well as caffeic and ferulic acids from CS. By a time of flight-mass spectrometric analysis of CS-administered plasma sample glucuronide and methylated conjugates of CS were identified, as well as glucuronide, methylated or sulfate conjugates of caffeic and ferulic acids. Consequently, CS was absorbed as intact form into rat blood, and partly degraded to caffeic and ferulic acids or metabolized by glucuronidation, methylation or sulfatation. |
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Authors:
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Ju Qiu; Nozomi Saito; Mai Noguchi; Keiichi Fukui; Kayo Yoshiyama; Kazusato Matsugano; Norihiko Terahara; Toshiro Matsui |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-2 |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: - ISSN: 1520-5118 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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