| Absolute measurement of androgen receptor mRNA in peripheral blood mononuclear, preputial skin and urethral mucosa cells of control individuals with phimosis using qRT-PCR. | |
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MedLine Citation:
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PMID: 22218452 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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INTRODUCTION: Androgen actions are exerted upon the androgen receptor (AR), and complete genital virilization of normal 46,XY individuals depends on adequate function and expression of the AR gene in a tissue-specific manner. OBJECTIVE: Standardization of normal ARmRNA in androgen-sensitive tissues. MATERIALS AND METHODS: In this study, we determined the quantitative amounts of ARmRNA in peripheral blood mononuclear, urethral mucosa and preputial skin cells of control subjects with phimosis by using RT-PCR. RESULTS: The mean (SD) values of AR expression in blood, urethra and prepuce were: 0.01 (0.01); 0.43 (0.32); 0.31 (0.36), respectively. CONCLUSION: The AR expression is low in blood and equivalent in urethral mucosa and preputial skin, which may be useful in the diagnosis of individuals with abnormal external genitalia. |
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Authors:
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Tatiane Sousa E Silva; Flavio Richetti; Daniela Patricia Palmeira Santos Cunha; Antonio Carlos Moreira Amarante; Jovelino Quintino de Souza Leão; Carlos Alberto Longui |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Arquivos brasileiros de endocrinologia e metabologia Volume: 55 ISSN: 1677-9487 ISO Abbreviation: Arq Bras Endocrinol Metabol Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2012-01-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0403437 Medline TA: Arq Bras Endocrinol Metabol Country: Brazil |
Other Details:
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Languages: eng Pagination: 665-8 Citation Subset: IM |
Affiliation:
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Molecular Medicine Laboratory, Physiology Department, Faculdade de Ciências Médicas, Santa Casa de São Paulo, São Paulo, SP, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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