| Absolute configuration of N-acetylaspartate in urine from patients with Canavan disease. | |
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MedLine Citation:
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PMID: 15902566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High-resolution 1H and 13C NMR of N-acetylaspartic acid as its 2-(S)-butyl diester allows the two enantiomers to be unambiguously identified. Analysis of urine samples from five patients with Canavan disease (N-aspartoacylase deficiency) showed that more than 95% of the excreted N-acetylaspartate had the S-configuration. |
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Authors:
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D Bal; A Gryff-Keller; W Gradowska |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of inherited metabolic disease Volume: 28 ISSN: 0141-8955 ISO Abbreviation: J. Inherit. Metab. Dis. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-05-19 Completed Date: 2005-09-15 Revised Date: 2007-03-21 |
Medline Journal Info:
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Nlm Unique ID: 7910918 Medline TA: J Inherit Metab Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 607-9 Citation Subset: IM |
Affiliation:
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Warsaw University of Technology, Faculty of Chemistry, Warsaw, Poland. domibal@yahoo.co.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aspartic Acid
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analogs & derivatives*,
chemistry,
urine Canavan Disease / urine* Humans Magnetic Resonance Spectroscopy Molecular Conformation Stereoisomerism |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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