Document Detail


Absolute configuration of N-acetylaspartate in urine from patients with Canavan disease.
MedLine Citation:
PMID:  15902566     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High-resolution 1H and 13C NMR of N-acetylaspartic acid as its 2-(S)-butyl diester allows the two enantiomers to be unambiguously identified. Analysis of urine samples from five patients with Canavan disease (N-aspartoacylase deficiency) showed that more than 95% of the excreted N-acetylaspartate had the S-configuration.
Authors:
D Bal; A Gryff-Keller; W Gradowska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of inherited metabolic disease     Volume:  28     ISSN:  0141-8955     ISO Abbreviation:  J. Inherit. Metab. Dis.     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-19     Completed Date:  2005-09-15     Revised Date:  2007-03-21    
Medline Journal Info:
Nlm Unique ID:  7910918     Medline TA:  J Inherit Metab Dis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  607-9     Citation Subset:  IM    
Affiliation:
Warsaw University of Technology, Faculty of Chemistry, Warsaw, Poland. domibal@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Aspartic Acid / analogs & derivatives*,  chemistry,  urine
Canavan Disease / urine*
Humans
Magnetic Resonance Spectroscopy
Molecular Conformation
Stereoisomerism
Chemical
Reg. No./Substance:
56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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