Document Detail

Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra.
MedLine Citation:
PMID:  8451417     Owner:  NLM     Status:  MEDLINE    
In vivo concentrations of cerebral metabolites were obtained by means of 52 single-voxel, localized proton magnetic resonance (MR) spectroscopic examinations of different regions of the brain performed in 26 healthy adults aged 21-32 years. The study was performed at 2.0 T with use of a circularly polarized head coil to ensure homogeneous radio-frequency excitation and signal reception. Proton MR spectra were obtained in the stimulated-echo acquisition mode under fully relaxed conditions (repetition time > or = 6,000 msec) and at short echo times (20 msec) to minimize corrections due to T1 and T2 attenuation and depict the spectra of metabolites with strongly coupled resonances. Absolute concentrations were obtained by means of calibration of resonance signal areas with those of pertinent metabolite solutions from separate studies and correction for coil loading and partial volume effects (eg, with perfused capillary networks and cerebrospinal fluid). The results provide a quantitative basis for studies of both normal human neurochemistry in vivo and metabolic alterations in diseases of the brain.
T Michaelis; K D Merboldt; H Bruhn; W Hänicke; J Frahm
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiology     Volume:  187     ISSN:  0033-8419     ISO Abbreviation:  Radiology     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-04-14     Completed Date:  1993-04-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401260     Medline TA:  Radiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  219-27     Citation Subset:  AIM; IM    
Max-Planck-Institut für Biophysikalische Chemie, Göttingen, Germany.
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MeSH Terms
Aspartic Acid / analogs & derivatives,  analysis
Brain Chemistry*
Choline / analysis
Creatine / analysis
Dipeptides / analysis
Inositol / analysis
Magnetic Resonance Spectroscopy*
Phosphocreatine / analysis
Reg. No./Substance:
0/Dipeptides; 3106-85-2/N-acetyl-1-aspartylglutamic acid; 56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 67-07-2/Phosphocreatine; 6917-35-7/Inositol; 997-55-7/N-acetylaspartate
Erratum In:
Radiology 1993 Jul;188(1):288

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