Document Detail


Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy.
MedLine Citation:
PMID:  12383574     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The purpose of the present study was to measure absolute concentrations of phosphocreatine (PCr) and adenosine triphosphate (ATP) in normal, hypertrophied, and failing human heart. BACKGROUND: Conflicting evidence exists on the extent of changes of high-energy phosphate metabolites in hypertrophied and failing human heart. Previous reports using phosphorus-31 magnetic resonance spectroscopy ((31)P-MRS) have quantified metabolites in relative terms only. However, this analysis cannot detect simultaneous reductions. METHODS: Four groups of subjects (n = 10 each), were studied: volunteers and patients with hypertensive heart disease (HHD), aortic stenosis, and dilated cardiomyopathy (DCM). Left ventricular (LV) function and mass were measured by cine magnetic resonance imaging. Absolute and relative concentrations of PCr and ATP were determined by (31)P-MRS with spatial localization with optimum point spread function. RESULTS: Left ventricular ejection fraction remained normal in HHD and aortic stenosis, but was severely reduced to 18% in DCM; LV mass was increased by 55%, 79%, and 68% respectively. In volunteers, PCr and ATP concentrations were 8.82 +/- 1.30 mmol/kg wet weight and 5.69 +/- 1.02 mmol/kg wet weight, and the PCr/ATP ratio was 1.59 +/- 0.33. High-energy phosphate levels were unaltered in HHD. In aortic stenosis, PCr was decreased by 28%, whereas ATP remained constant. In DCM, PCr was reduced by 51%, ATP by 35%, and reduction of the PCr/ATP ratio by 25% was of borderline significance (p = 0.06). Significant correlations were observed among energetic and functional variables, with the closest relations for PCr. CONCLUSIONS: In human heart failure due to DCM, both PCr and ATP are significantly reduced. Ratios of PCr to ATP underestimate changes of high-energy phosphate levels.
Authors:
Meinrad Beer; Tobias Seyfarth; Jörn Sandstede; Wilfried Landschütz; Claudia Lipke; Herbert Köstler; Markus von Kienlin; Kerstin Harre; Dietbert Hahn; Stefan Neubauer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  40     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-10-17     Completed Date:  2002-11-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1267-74     Citation Subset:  AIM; IM    
Affiliation:
Institut für Röntgendiagnostik, Würzburg, Germany. meinrad.beer@mail.uni-wuerzburg.de
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MeSH Terms
Descriptor/Qualifier:
Adenosine Triphosphate / analysis*
Adult
Aged
Aged, 80 and over
Aortic Valve Stenosis / diagnosis*,  metabolism*,  physiopathology
Bias (Epidemiology)
Cardiomyopathy, Dilated / diagnosis*,  metabolism*,  physiopathology
Case-Control Studies
Energy Metabolism
Female
Humans
Hypertension / complications*
Hypertrophy, Left Ventricular / diagnosis*,  etiology,  metabolism*,  physiopathology
Imaging, Three-Dimensional / methods*
Magnetic Resonance Imaging
Magnetic Resonance Spectroscopy / methods*
Male
Middle Aged
Myocardium / chemistry*,  metabolism
Phosphocreatine / analysis*
Phosphorus Isotopes / diagnostic use*
Stroke Volume
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Phosphorus Isotopes; 56-65-5/Adenosine Triphosphate; 67-07-2/Phosphocreatine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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