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Absolute blood eosinophil count and 1-year mortality risk following hospitalization with acute heart failure.
MedLine Citation:
PMID:  22082878     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: In acute heart failure (AHF), hemoglobin, red cell distribution width, mean platelet volume, leukocytes, and relative lymphocyte count have been associated with mortality. It is not known whether absolute blood neutrophil, eosinophil, and monocyte counts are mortality predictors. METHODS: One hundred and seventy-six patients hospitalized due to AHF were enrolled. Treatment modalities and comorbidities influencing leukocyte counts were excluded. Hemogram, pro-brain natriuretic peptide, D-dimer, biochemistry, thyroid hormones, sensitive C-reactive protein, and echocardiography were obtained. Cardiovascular deaths during the first year after hospitalization were determined. RESULTS: Leukocyte and absolute neutrophil count were significantly higher and absolute lymphocyte count and absolute eosinophil count (AEC) were significantly lower in deceased patients than patients who survived. Groups were similar in terms of monocyte counts. BMI albumin, estimated glomerular filtration rate, free T3, ejection fraction were significantly lower, and ferritin, uric acid, D-dimer, pro-brain natriuretic peptide were significantly higher in deceased patients. Mitral regurgitation, hypotension, hyponatremia, and acute renal failure were also significantly more frequent among the deceased group. Binary logistic regression analysis employing significant variables showed that lower BMI, lower ejection fraction, hyponatremia, lower free T3, and lower AEC were independent predictors of death and as a whole were responsible from 81.8% of cardiovascular deaths. Death rate among patients with an AEC of 0.02 n/l×10 or less was 4.4-fold higher than patients with an AEC of more than 0.02 n/l×10. CONCLUSION: AEC of AHF patients measured at admission was found to be a stronger predictor of mortality than all other hemogram parameters and this is consistent with the increased sympatho-adrenal activity theory.
Authors:
Mehmet Ali Cikrikcioglu; Pinar Soysal; Digdem Dikerdem; Mustafa Cakirca; Rumeyza Kazancioglu; Servet Yolbas; Hafize Erkal; Mehmet Hursitoglu; Tulin Kurt Karakose; Muharrem Kiskac; Mehmet Akkaya; Mehmet Zorlu; Muhammed Emin Akkoyunlu; Tufan Tukek
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-11
Journal Detail:
Title:  European journal of emergency medicine : official journal of the European Society for Emergency Medicine     Volume:  -     ISSN:  1473-5695     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9442482     Medline TA:  Eur J Emerg Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aInternal Medicine Clinic bCardiology Clinic cIntensive Care Unit, Faculty of Medicine, Bezmialem Vakif University, Fatih dPrivate Yesiltepe Clinic, Zeytinburnu eInternal Medicine Clinic, Sisli Etfal Training and Research Hospital fInternal Medicine Clinic, Okmeydani Training and Research Hospital, Sisli gCardiology Clinic, Gaziosmanpasa Private Duygu Hospital, Gaziosmanpasa, Istanbul, Turkey.
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