| Absolute Hypoxic Exercise Training Enhances in vitro Thrombin Generation by Increasing Procoagulant Platelet-derived Microparticles under High Shear Stress in Sedentary Men. | |
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MedLine Citation:
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PMID: 23252666 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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High shear stress (HS) associated with artery stenosis facilitates thrombin generation (TG) by increasing the release of procoagulant platelet-derived microparticles (PDMPs). Physical exercise and hypoxia may paradoxically modulate vascular thrombotic risks. This study investigated how exercise training with/without hypoxia affected TG mediated by PDMPs under physio-pathological shear flows. Seventy five sedentary males were randomly divided into five groups (n=15 in each group): 21%O2 (normoxic control, NC) or 15%O2 (hypoxic control, HC) at rest or were trained at 50% of peak work-rate under 21%O2 (normoxic training, NT) or 15%O2 (hypoxic-absolute training, HAT), or 50% of heart rate reserve under 15%O2 (hypoxic-relative training, HRT) for 30 minutes/day, 5 days/week for 4 weeks. The PDMP characteristics and dynamic TG were measured by flow cytometry and thrombinography, respectively. Before the intervention, strenuous exercise markedly increased PDMP count (14.8%) and TG rate (19.5%) in PDMP-rich plasma at 100 dyne/cm2 of shear stress (p<0.05). After interventions, both NT and HRT significantly attenuated the enhancements of the HS-induced PDMPs (4.7% and 4.9%) and TG rate (3.8% and 3.0%) (p<0.05) by severe exercise. Conversely, HAT notably promoted PDMP count (37.3%) and TG rate (38.9%) induced by HS (p<0.05), concurrence with increasing plasma tissue factor and coagulation factor V levels at rest or following exercise. We conclude that both HRT and NT depress similar HS-mediated TG during exercise, but HAT accelerates the prothrombotic response to vigorous exercise. The findings provide new insights into how exercise training under a hypoxic condition influences the risk of thrombosis associated with stenotic arteries. |
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Authors:
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Yu-Wen Chen; I-Jing Chen; Jong-Shyan Wang |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-12-20 |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: - ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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