Document Detail

Absolute Hypoxic Exercise Training Enhances in vitro Thrombin Generation by Increasing Procoagulant Platelet-derived Microparticles under High Shear Stress in Sedentary Men.
MedLine Citation:
PMID:  23252666     Owner:  NLM     Status:  Publisher    
High shear stress (HS) associated with artery stenosis facilitates thrombin generation (TG) by increasing the release of procoagulant platelet-derived microparticles (PDMPs). Physical exercise and hypoxia may paradoxically modulate vascular thrombotic risks. This study investigated how exercise training with/without hypoxia affected TG mediated by PDMPs under physio-pathological shear flows. Seventy five sedentary males were randomly divided into five groups (n=15 in each group): 21%O2 (normoxic control, NC) or 15%O2 (hypoxic control, HC) at rest or were trained at 50% of peak work-rate under 21%O2 (normoxic training, NT) or 15%O2 (hypoxic-absolute training, HAT), or 50% of heart rate reserve under 15%O2 (hypoxic-relative training, HRT) for 30 minutes/day, 5 days/week for 4 weeks. The PDMP characteristics and dynamic TG were measured by flow cytometry and thrombinography, respectively. Before the intervention, strenuous exercise markedly increased PDMP count (14.8%) and TG rate (19.5%) in PDMP-rich plasma at 100 dyne/cm2 of shear stress (p<0.05). After interventions, both NT and HRT significantly attenuated the enhancements of the HS-induced PDMPs (4.7% and 4.9%) and TG rate (3.8% and 3.0%) (p<0.05) by severe exercise. Conversely, HAT notably promoted PDMP count (37.3%) and TG rate (38.9%) induced by HS (p<0.05), concurrence with increasing plasma tissue factor and coagulation factor V levels at rest or following exercise. We conclude that both HRT and NT depress similar HS-mediated TG during exercise, but HAT accelerates the prothrombotic response to vigorous exercise. The findings provide new insights into how exercise training under a hypoxic condition influences the risk of thrombosis associated with stenotic arteries.
Yu-Wen Chen; I-Jing Chen; Jong-Shyan Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-20
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  -     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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