Document Detail


The Absolute Configuration of (+)- and (-)-erythro-Mefloquine.
MedLine Citation:
PMID:  23616269     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The controversy over the absolute configuration of (+)-erythro-mefloquine, the less psychosis-causing enantiomer of the anti-malarial drug Lariam, has been resolved by Mosher ester crystallization. The configuration determined previously by physical methods is correct, while the configuration determined by three enantioselective syntheses is wrong.
Authors:
Michael Müller; Claudia M Orben; Nina Schützenmeister; Manuel Schmidt; Andrei Leonov; Uwe M Reinscheid; Birger Dittrich; Christian Griesinger
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-24
Journal Detail:
Title:  Angewandte Chemie (International ed. in English)     Volume:  -     ISSN:  1521-3773     ISO Abbreviation:  Angew. Chem. Int. Ed. Engl.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-4-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370543     Medline TA:  Angew Chem Int Ed Engl     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Affiliation:
Max-Planck-Institut für Biophysikalische Chemie, Department of NMR-Based Structural Biology, Am Fassberg 11, 37077 Göttingen (Germany).
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