| Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment. | |
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MedLine Citation:
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PMID: 19071194 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hippocampus displayed progressively gender-associated damage in Alzheimer's disease. However, gender effects have been largely neglected in studies of amnestic type mild cognitive impairment (aMCI) patients who were believed to represent an early stage of this disease. The goal of this study was to use in vivo neuroimaging techniques to determine whether there were any evidences of gender differences in hippocampal atrophy in aMCI. A region of interest-based magnetic resonance imaging approach was used to compare hippocampal volume between aMCI patients (22 male, 17 female) and normal aging controls (12 male, 11 female). Independent of group, male hippocampal volumes were larger than female volumes and right hippocampal volumes were typically smaller than left volumes. Hippocampal volumes were significantly reduced in the clinical group but no gender differences were noted in terms of degree of atrophy present. However, female patients showed more impaired cognitive function than male patients despite this apparent equivalence in atrophy. The absence of a gender difference suggested that early neuropathological progression might be independent of gender. However, the data also suggested female aMCI patients had an increased vulnerability to cognitive impairment earlier in the illness course. |
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Authors:
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Feng Bai; Zhijun Zhang; David R Watson; Hui Yu; Yongmei Shi; Wanlin Zhu; Liang Wang; Yonggui Yuan; Yun Qian |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-11-30 |
Journal Detail:
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Title: Neuroscience letters Volume: 450 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-03-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 85-9 Citation Subset: IM |
Affiliation:
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School of Clinical Medicine, Southeast University, Nanjing 210009, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amnesia / complications, pathology* Atrophy Cognition Disorders / complications, pathology* Female Hippocampus / pathology* Humans Magnetic Resonance Imaging / methods Male Neuropsychological Tests Sex Characteristics* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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