Document Detail

Absent gender differences of hippocampal atrophy in amnestic type mild cognitive impairment.
MedLine Citation:
PMID:  19071194     Owner:  NLM     Status:  MEDLINE    
Hippocampus displayed progressively gender-associated damage in Alzheimer's disease. However, gender effects have been largely neglected in studies of amnestic type mild cognitive impairment (aMCI) patients who were believed to represent an early stage of this disease. The goal of this study was to use in vivo neuroimaging techniques to determine whether there were any evidences of gender differences in hippocampal atrophy in aMCI. A region of interest-based magnetic resonance imaging approach was used to compare hippocampal volume between aMCI patients (22 male, 17 female) and normal aging controls (12 male, 11 female). Independent of group, male hippocampal volumes were larger than female volumes and right hippocampal volumes were typically smaller than left volumes. Hippocampal volumes were significantly reduced in the clinical group but no gender differences were noted in terms of degree of atrophy present. However, female patients showed more impaired cognitive function than male patients despite this apparent equivalence in atrophy. The absence of a gender difference suggested that early neuropathological progression might be independent of gender. However, the data also suggested female aMCI patients had an increased vulnerability to cognitive impairment earlier in the illness course.
Feng Bai; Zhijun Zhang; David R Watson; Hui Yu; Yongmei Shi; Wanlin Zhu; Liang Wang; Yonggui Yuan; Yun Qian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-11-30
Journal Detail:
Title:  Neuroscience letters     Volume:  450     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-03-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  85-9     Citation Subset:  IM    
School of Clinical Medicine, Southeast University, Nanjing 210009, China.
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MeSH Terms
Amnesia / complications,  pathology*
Cognition Disorders / complications,  pathology*
Hippocampus / pathology*
Magnetic Resonance Imaging / methods
Neuropsychological Tests
Sex Characteristics*

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